CD28 agonists(T-cell-specific surface glycoprotein CD28 agonists), CSF-2R stimulants(Granulocyte-macrophage colony-stimulating factor receptor stimulants), CTLA4 stimulants(Cytotoxic T-Lymphocyte-Associated Antigen 4 stimulants)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

RADIENT CONSULTING SRL

Active Organization

RADIENT CONSULTING SRL

Inactive Organization

Radient Pharmaceuticals Corp.

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

100 Clinical Results associated with B7-2/GM-CSF cancer gene therapy(Radient Consulting)

100 Translational Medicine associated with B7-2/GM-CSF cancer gene therapy(Radient Consulting)

100 Patents (Medical) associated with B7-2/GM-CSF cancer gene therapy(Radient Consulting)

Literatures (Medical) associated with B7-2/GM-CSF cancer gene therapy(Radient Consulting)

01 Oct 2011·Journal of Veterinary Pharmacology and TherapeuticsQ3 · AGRICULTURAL & FORESTRY SCIENCE

The pharmacokinetics of hydrochlorothiazide in the camel

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: I. A. Wasfi ; N.A. Al Katheeri

The purposes of this study were to characterize the pharmacokinetics (PK) of hydrochlorothiazide (HCT) in camels and to develop a sensitive liquid chromatog. tandem mass spectrometry (LC/MS/MS) method for the detection of HCT in camel fluids and to advice on a withdrawal period before camel racing following a therapeutic dose of HCT.Hydrochlorothiazide resulted in profound urine production in camels but no adverse effects were observedThe AUC_0-∞ of the double dose was twice that of the first dose and was significantly different from it.However, V_ss, CI_T, T_1/2β and mean residence time were similar in both dose regimens suggesting linear kinetics in the dose range used.The LC/MS/MS method used in this study proved to be sensitive and efficient and is superior to HPLC methods that lacked sensitivity and to GC, and GC/MS methods which required cumbersome derivatization steps.He LC-MS/MS method reported in this study, with a LOQ of 2 ng/mL, could easily detect HCT 1-2 days after administration.Therefore, as a precautionary measure due to inter-animal variation, we propose withholding HCT administration before racing for a min. period of 3 days.

01 Dec 1999·European Journal of PharmacologyQ3 · MEDICINE

[3H]β-CIT: a radioligand for dopamine transporters in rat brain tissue

Q3 · MEDICINE

Article

Author: Tarazi, F. I. ; Fisser, R. ; Neumeyer, J. L. ; Wang, S. ; Kula, N. S. ; Trometer, J. ; Baldessarini, R. J.

[3H]2-beta-carbomethoxy-3-beta-[4'-iodophenyl]tropane (beta-CIT) was prepared and evaluated. With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. Affinity and selectivity for 53 compounds assayed with [3H]beta-CIT and standard DAT radioligand [3H]GBR-12935 were highly correlated (r0.95). [3H]beta-CIT is proposed as a useful, high-affinity DAT radioprobe.

100 Deals associated with B7-2/GM-CSF cancer gene therapy(Radient Consulting)

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Phase 2	Canada	Radient Pharmaceuticals Corp.	-
Neoplasms	Phase 1	-	RADIENT CONSULTING SRL	-

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