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Clinical Trials associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)评价吸附无细胞百白破灭活脊髓灰质炎联合疫苗应用于3月龄及以上健康人群的安全性和免疫原性的随机、盲法、平行阳性对照Ⅰ期临床试验
[Translation] A randomized, blinded, parallel, positive-controlled phase I clinical trial to evaluate the safety and immunogenicity of adsorbed acellular diphtheria, pertussis, and tetanus combined with inactivated poliomyelitis vaccine in healthy people aged 3 months and above
评价吸附无细胞百白破灭活脊髓灰质炎联合疫苗应用于3月龄及以上健康人群的安全性和免疫原性。
[Translation] To evaluate the safety and immunogenicity of adsorbed acellular diphtheria, pertussis and tetanus combined with inactivated poliomyelitis vaccine in healthy people aged 3 months and above.
100 Clinical Results associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)
100 Translational Medicine associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)
100 Patents (Medical) associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)
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Literatures (Medical) associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)Frontiers in MicrobiologyQ2 · BIOLOGY
Dose-Sparing Intradermal DTaP-sIPV Immunization With a Hollow Microneedle Leads to Superior Immune Responses
Q2 · BIOLOGY
ArticleOA
Author: Cai, Lukui ; Gu, Qin ; Wang, Xiaoyu ; Shi, Li ; Sun, Mingbo ; Li, Jingyan ; Jiang, Wenwen ; Ma, Yan ; Zuo, Weilun ; Zhang, Mengyao
Dose-sparing intradermal (ID) vaccination may induce the same immune responses as intramuscular (IM) vaccination, which can increase vaccine supplies and save costs. In this study, rats were immunized with fractional-dose of Sabin-derived IPV combined with diphtheria-tetanus-acellular pertussis vaccine (DTaP-sIPV) intradermally with hollow microneedle devices called MicronJet600 and the vaccine immunogenicity and efficacy were evaluated and compared with those of full-dose intramuscular immunization. We tested levels of antibodies and the subclass distribution achieved via different immunization routes. Furthermore, gene transcription in the lung and spleen, cytokine levels and protection against Bordetella pertussis (B. pertussis) infection were also examined. The humoral immune effect of DTaP-sIPV delivered with MicronJet600 revealed that this approach had a significant dose-sparing effect and induced more effective protection against B. pertussis infection by causing Th1/Th17 responses. In conclusion, ID immunization of DTaP-sIPV with the MicronJet600 is a better choice than IM immunization, and it has the potential to be a new DTaP-sIPV vaccination strategy.
100 Deals associated with Diphtheria,Tetanus, Acellular Pertussis and Poliomyelitis Combined Vaccine, Inactivated, Adsorbed(Minhai Biological)