Delving into the Latest Updates on Melitracen Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Melitracen hydrochloride (JAN/USAN)

+ [3]

Target

MATs

Action-

Mechanism

Monoamine reuptake inhibitor

Therapeutic Areas

Nervous System Diseases

Active Indication

Depressive Disorder

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC21H26ClN

InChIKeyRADLXCPDUXFGFF-UHFFFAOYSA-N

CAS Registry10563-70-9

View All Structures (2)

To examine the prevalence of treatment indications for antidepressants and assessed temporal trends in antidepressant prescribing for depression among adult patients in primary health care facilities (PHFs) in China. Descriptive study of antidepressant prescriptions written by primary care physicians. Setting participants: Patients aged 18 years and above in 67 PHFs in Dongcheng district in Beijing between 1 January 2014 and 31 December 2022. Deidentified information including patient demographics,antidepressants prescribed,and corresponding diagnoses were extracted from the prescribing system. The primary outcome was the treatment indications for all antidepressants prescribed between 2014 and 2022. Prescriptions were classified as on-label or off-label depending on whether the drug was approved for the indication by China's National Medical Products Administration by September 2022. A total of 42379 antidepressant prescriptions were identified between 2014 and 2022. Only 21.21 % of antidepressant prescriptions were indicated for depression. Anxiety disorders (31.43 %), insomnia (20.07 %), pain(19.12 %) and digestive system disorders (16.34 %) are also frequently prescribed antidepressants by physicians. For these indications, the most frequently prescribed antidepressant was flupentixol/melitracen and sertraline.For 36.32 % of all antidepressant prescriptions,physicians prescribed a drug for an off-label indication,especially insomnia and pain.Physicians also prescribed antidepressants for several indications that were off-label for all antidepressants, including digestive system disorders and migraine. This study found compound antidepressants are widely prescribed and used off-label indications.There is a need for more evidence to evaluate the clinical outcomes associated with off-label antidepressant indications for older adults to optimise prescribing decisions at PHFs.

01 Jan 2025·Clinical Laboratory

A Case of Pseudo Prolactin Elevation Caused by Medication

Article

Author: Liu, Lan-Bing ; Sun, Hong-Gang ; He, Li-Qin

BACKGROUNDAfter the patient had a long course of disease and symptoms of bilateral breast milk secretion, the doctor first considered that the patient had breast cancer. After screening and excluding the breast, he found that the patient had high prolactin, and suspected that the patient had a pituitary tumor. After breast cancer and pituitary adenoma were excluded, the doctor suspected that there might be interference of macroprolactin. After PEG treatment, we also excluded the interference of macroprolactin. After repeated communication with doctors and patients, we found that the patient had gone to a psychiatric hospital for treatment and taken the antidepressant drug Deanxit (Flupentixol and Melitracen tablets).METHODSFlupentixol acts by antagonizing hypothalamic prolactin releasing inhibitory factors, reducing dopamine release, leading to hyperprolactinemia.RESULTSThe patient's examination found that prolactin was 3,172.9 mIU/L (normal range 108.80 - 557.10 mIU/L), and after PEG treatment, it was 2,692.86 mIU/L. Patient stopped using Deanxit for one month, and prolactin levels were 302.8 mIU/L.CONCLUSIONSOnly effective communication between laboratory and clinical departments can make laboratory results more accurate and provide strong guarantees for clinical diagnosis and treatment.

01 Oct 2024·Journal of Mid-life Health

Antidepressant-induced Hyponatremia in Postmenopausal Females: A Case Series

Article

Author: Garg, Ruchika ; Agrawal, Prabhat Kumar ; Yadav, Shiv Sagar ; Gautam, Ashish ; Panda, Sandipta Kumar

ABSTRACTHyponatremia is the most common electrolyte imbalance observed in hospitalized as well as outdoor patients. Antidepressants such as selective serotonin receptor inhibitors and tricyclic antidepressants are reported among the most common drugs causing hyponatremia, especially in the elderly and in patients with known risk factors for hyponatremia. However, there have been only a few case reports of hyponatremia associated with antidepressants such as mirtazapine and flupentixol/melitracen. The exact mechanism of hyponatremia with the use of antidepressants is not known; however, syndrome of inappropriate antidiuretic hormone secretion (SIADH) is presumed to be the reason. Here, we report two cases of antidepressant drug-induced hyponatremia in two postmenopausal females with no other risk factor for hyponatremia: one associated with mirtazapine and the other with flupentixol/melitracen.

100 Deals associated with Melitracen Hydrochloride

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External Link

KEGG	Wiki	ATC	Drug Bank
D01110	Melitracen Hydrochloride	N06AA14	DB13384

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Depressive Disorder	-	-	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EHA2019	Not Applicable	Postoperative Nausea and Vomiting	160	Control group	kkumlfxxqs(qfkyascqtm) = svaqwepyud hzjpvwujrj (qlbmqozpcw )	-	15 Jun 2019
				Lupentixol melitracen group	kkumlfxxqs(qfkyascqtm) = rhqzsbhvgu hzjpvwujrj (qlbmqozpcw )