Delving into the Latest Updates on Felbinac with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Felbinac (JP17/USAN/INN), Felbinac tape, Felbinac transdermal

+ [18]

Target

COXs

Action

inhibitors

Mechanism

COX inhibitors(Cyclooxygenases inhibitors)

Therapeutic Areas

Immune System DiseasesNervous System DiseasesSkin and Musculoskeletal Diseases+ [1]

Active Indication

Low Back PainBursitisMusculoskeletal Pain+ [3]

Inactive Indication

Soft Tissue Injuries

Originator Organization

Teikoku Seiyaku Co. Ltd.

Active Organization

Teikoku Seiyaku Co. Ltd.

Henan Lingrui Pharmaceutical Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (25 Sep 1986),

BursitisMusculoskeletal PainOsteoarthritis+ [2]

Regulation-

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Structure/Sequence

Molecular FormulaC14H12O2

InChIKeyQRZAKQDHEVVFRX-UHFFFAOYSA-N

CAS Registry5728-52-9

Herein, we describe a nickel-catalyzed reductive decarboxylative difluoromethylation reaction of alkenes using inexpensive and easy-to-handle difluoroacetic anhydride (DFAA)/pyridine N-oxide reagent system.A variety of C(sp³)-CF₂H containing compounds were prepared through a hydrodifluoromethylation process.Besides, various gem-difluoroalkenes bearing CF₂H group were synthesized via defluorinative reductive cross-coupling process from trifluoromethyl-substituted alkenes using this new reaction system.Difluoroacetic anhydride has been then extended to other common alkyl anhydrides, and the corresponding hydroalkylation and defluoroalkylation processes have been successfully achieved.This method features broad substrate scope, good functional group tolerance as well as high efficiency.

01 Mar 2025·Tetrahedron

4-Aminobenzotriazole directed palladium-catalyzed C–H acetoxylation and intramolecular amination reaction

Author: Li, Yuanming ; Li, Chengqian ; Song, Zhiguang ; Fan, Yupeng ; Hu, Jianliang ; Huang, Wangsheng ; Wang, Zhuo

We present an approach for ortho C(sp²)-H acylation and intramol. amination reactions, employing 4-amino-benzotriazole (ABTA) as a bidentate directing group.This method is facilitated by a palladium catalyst in combination with iodobenzene diacetate.Our approach efficiently yields acetoxylation and intramol. amination products from a variety of acylamide substrates, including arylcarboxamides and arylacetamides.

01 Feb 2025·Tetrahedron

An efficient method for thioesterification of carboxylic acid with sulfenylchloride

Author: Zi, You ; Wang, Mengke ; Chen, Jiahong ; Huang, Weichun

A mild and convenient method for synthesizing thioesters has been developed, from sulfenylchlorides and carboxylic acids via a phosphine mediated umpolung process.This approach efficiently produces a broad spectrum of thioesters from readily available carboxylic acids, including primary, secondary and tertiary types, as well as bioactive mols.The successful gram-scale reactions also validate its scalability and practical application.

100 Deals associated with Felbinac

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External Link

KEGG	Wiki	ATC	Drug Bank
D01675	Felbinac	M02AA08	DB07477

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Low Back Pain	Japan	Teikoku Seiyaku Co. Ltd.	28 Feb 1989
Bursitis	Japan	Teikoku Seiyaku Co. Ltd.	25 Sep 1986
Musculoskeletal Pain	Japan	Teikoku Seiyaku Co. Ltd.	25 Sep 1986
Osteoarthritis	Japan	Teikoku Seiyaku Co. Ltd.	25 Sep 1986
Post-traumatic pain	Japan	Teikoku Seiyaku Co. Ltd.	25 Sep 1986
Tenosynovitis	Japan	Teikoku Seiyaku Co. Ltd.	25 Sep 1986

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Osteoarthritis	Phase 2	China	Henan Lingrui Pharmaceutical Co., Ltd.	21 Jan 2014
Soft Tissue Injuries	Discovery	China	Henan Lingrui Pharmaceutical Co., Ltd.	15 Nov 2011