Last update 04 Apr 2026

INCB-186748

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
INCB-186748
Target
KRAS G12D
Action
modulators
Mechanism
KRAS G12D modulators(GTPase KRas G12D modulators)
Therapeutic Areas
Neoplasms
Active Indication
Locally Advanced Malignant Solid NeoplasmMetastatic Solid Tumor
Inactive Indication-
Originator Organization
Incyte Corp.Incyte Corp.
Active Organization
Incyte Corp.Incyte Corp.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with INCB-186748
NCT06818812
/ Active, not recruitingPhase 1
A Phase 1, Open-Label, Multicenter Study of INCB186748 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
100 Clinical Results associated with INCB-186748
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100 Translational Medicine associated with INCB-186748
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100 Patents (Medical) associated with INCB-186748
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100 Deals associated with INCB-186748
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Locally Advanced Malignant Solid NeoplasmPhase 1
United States
Incyte Corp.Incyte Corp.
27 Mar 2025
Metastatic Solid TumorPhase 1
United States
Incyte Corp.Incyte Corp.
27 Mar 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Clinical Trial

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Approval

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Regulation

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