Multifunctional pH-responsive films were fabricated via layer-by-layer deposition of gelatin, chitosan, and carboxymethyl cellulose (CMC), incorporating selenium nanoparticles (SeNPs) and beetroot extract (BTE), to monitor and preserve beef freshness. SeNPs were synthesized and characterized via various techniques. BTE exhibited promising functional properties, and films demonstrated a significant color transition from red to yellow across pH 2-14. SeNPs and BTE incorporation enhanced UV resistance, mechanical properties, and reduced water and oxygen permeability. AFM revealed distinct changes in film surface morphology upon the addition of SeNPs and BTE. The films displayed strong antibacterial and antioxidant activities, making them suitable for food packaging applications. Molecular docking simulations indicated strong binding affinities between betalains and gelatin, while CMC stabilized the multilayer structure. These multifunctional films extended beef shelf life and monitored its freshness by transitioning film color upon spoilage, introducing novel nanoparticle-incorporated multilayer films for intelligent packaging and effective preservation of animal-derived food freshness.

01 Mar 2025·International Journal of Biological Macromolecules

Preparation, characterization, and stability of selenium nanoparticles decorated with Mori Fructus polysaccharide and its protective effects in bisphenol A-induced Sertoli cells

Article

Author: Zhao, Liyan ; Zheng, Ruili ; Sun, Zhipeng ; Qian, Yanfang ; Liu, Siyi ; Cao, Mingyuan ; Chen, Guitang

Bisphenol A (BPA) is an endocrine disruptor universally present in food packaging, which may cause oxidative stress and reproductive toxicity through migration to food and ingestion then. Both Mori Fructus and selenium have excellent antioxidant ability and good therapeutic effects on reproductive improvement. Hence, in this work, Mori Fructus polysaccharide (MFP) was selected as a stabilizer to synthesize MFP‑selenium nanoparticles (MFP-SeNPs) by chemical reduction method. The structural properties, stability and antioxidant activity of MFP-SeNPs were subsequently characterized and studied. The results suggested that spherical MFP-SeNPs (average size 80.73 nm, zeta potential -31.8 mV) with zero-valent and well dispersion was successfully synthesized with 1 mg/mL MFP as a stabilizer, which could be stabilized at 4 °C for 35 d. Compared with MFP and SeNPs, MFP-SeNPs had stronger radical scavenging ability, it could also decrease the levels of MDA and ROS and enhance the GSH-px and SOD activity through PI3K/Akt pathways in BPA-induced TM4 cells. Taken together, MFP-SeNPs could become a potential antioxidant to improve male reproductive functions in the future food field.

01 Mar 2025·International Journal of Biological Macromolecules

Chitosan and alginate/Aspergillus flavus-mediated nanocomposite films for preservation of postharvest tomatoes

Article

Author: Abd El-Ghany, Mohamed N ; Soliman, Soliman M A ; El-Basiouny, Nesren M ; Khalil, Neveen M

The isolated Aspergillus flavus NSRN22 was used for green synthesis of silver and selenium nanoparticles (AgNPs and SeNPs). New food packaging films produced by combining each type of NPs with chitosan (CS) or sodium alginate (SA) were characterized. Transmission electron microscopy revealed that the average particle size was lower in case of AgNPs (9 to 14.7 nm) than SeNPS (36.8 to 53.5 nm). FTIR revealed a stronger connection between CS and NPs compared to SA and NPs. Tensile strength of CS (0.55 MPa) or SA (2.42 MPa) increased to 3.82, 4.73, 5.96, and 3.87 MPa for nanocomposite films of CS/AgNPs, CS/SeNPs, SA/AgNPs, and SA/SeNPs, respectively. Contrarily, water vapor pressures of SA (2132.57 g/m².day) and CS (2021.71 g/m².day) decreased to 1922.47, 1871.45, 1822.95 and 1795.29 g/m².day for SA/AgNPs, SA/SeNPs, CS/AgNPs and CS/SeNPs, respectively. The respective statistical minimum inhibitory concentrations for SA/AgNPs, CS/AgNPs, CS/SeNPs, SA/SeNPs, CS and SA were 1000, 1018, 1030, 1055, 1130 and 1135 μg/5 mL. CS/SeNPs were superior in terms of thermal stability (21 % weight loss), antioxidant activity (58.75 %), and normal cells viability (100 %). They demonstrated excellent preservation of tomatoes' natural color and texture, significantly reduced mold growth, and thus are ideal as antimicrobial and safe packaging materials.

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Indication	Highest Phase	Country/Location	Organization	Date
Parkinson Disease	Preclinical	CN	South China University of Technology	01 Jul 2024

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