Delving into the Latest Updates on SB-T-12843 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action

inducers

Mechanism

Apoptosis inducers

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Stony Brook University

Active Organization-

Inactive Organization

Stony Brook University

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

A series of new taxoids bearing difluoromethyl group at the C-3' position and modifications at the C-10 and C-14 positions has been synthesized and their biological activities studied. The in vitro cytotoxicity assay results indicate that these newly developed taxoids exhibit comparable to several times better activity against drug-sensitive cell line LCC6-WT, and 40-70 times better activity against the corresponding drug-resistant cancer cell line LCC6-MDR as compared to that of paclitaxel. Apoptosis analysis has revealed the exceptional activity of SB-T-12843 (1e) in inducing apoptosis in both MDR-bearing and MDR-negative cancer cells.

100 Deals associated with SB-T-12843

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