Last update 21 Nov 2024

Pivampicillin

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Ampicillin pivaloyloxymethyl ester, Pivaloylampicillin, Pivaloyloxymethyl ampicillinate

+ [3]

Target

PBPs

Mechanism

PBPs inhibitors(Bacterial penicillin-binding protein inhibitors)

Therapeutic Areas

Infectious DiseasesUrogenital Diseases

Active Indication

Gonorrhea

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure

Molecular FormulaC22H29N3O6S

InChIKeyZEMIJUDPLILVNQ-ZXFNITATSA-N

CAS Registry33817-20-8

View All Structures (2)

100 Clinical Results associated with Pivampicillin

100 Translational Medicine associated with Pivampicillin

100 Patents (Medical) associated with Pivampicillin

268

Literatures (Medical) associated with Pivampicillin

01 Dec 2021·Gut PathogensQ3 · MEDICINE

Helicobacter cinaedi bacteraemia secondary to enterocolitis in an immunocompetent patient

Q3 · MEDICINE

ArticleOA

Author: Rasmussen, Sofie Larsen ; Nielsen, Hans Linde ; Tarpgaard, Irene Harder ; Ørsted, Iben

AbstractBackgroundHelicobacter cinaediare motile, gram-negative spiral rods with a natural reservoir in the intestinal tract of hamsters and rhesus monkeys. In humans,H. cinaedihas been reported in different human infections like fever, abdominal pain, gastroenteritis, proctitis, diarrhoea, erysipelas, cellulitis, arthritis, and neonatal meningitis typically diagnosed by positive blood cultures. Even thoughH. cinaedihas been detected from human blood and stool the entry ofH. cinaediinto the blood stream was undocumented until quite recently. The use of pulse-field gel electrophoresis (PFGE) demonstrated that stool- and blood-derivedH. cinaedistrains were consistent.Case presentationHere, we describe a rare Danish case ofH. cinaedibacteraemia in an immunocompetent 44-year-old male with diarrhoea. We isolatedH. cinaedifrom a blood culture taken at admission, and from a FecalSwab taken at day six despite ongoing antibiotic therapy. Next, we made a genetic comparison of both isolates by use of Multi-locus sequence typing (MLST)- and Single nucleotide polymorphism (SNP)-analysis. The two isolates were identical with zero SNPs and by use of MLST the isolate was identified as a novel ST20, confirming previous data of the intestinal tract as a route ofH. cinaedibacteraemia. The results of our AST showed a resistance pattern with higher MICs for ciprofloxacin and clarithromycin than for ampicillin, amoxicillin, gentamicin, and imipenem. The patient was cured with targeted therapy with pivampicillin; however, the primary source of transmission was unknown.ConclusionsIn conclusion, this case ofH. cinaedibacteraemia secondary to enterocolitis in an immunocompetent patient provide clear evidence that one route of infection occurs through translocation from the intestinal tract to the bloodstream.Helicobacter cinaedifrom blood and faeces were identical with a novel ST20, resistant to ciprofloxacin and clarithromycin however, the patient was cured with oral pivampicillin.

01 Jan 2021·International Archives of Allergy and ImmunologyQ3 · MEDICINE

Intradermal Testing Identifies 1 in 4 Patients with Nonimmediate Penicillin Allergy

Q3 · MEDICINE

Article

Author: Fransson, Sara ; Kappel, Mogens ; Elberling, Jesper ; Mosbech, Holger F ; Garvey, Lene H

Background: Intradermal testing with delayed reading (IDTdr), used routinely in many centers, may identify delayed reactions to penicillins. However, few studies have compared the results of IDTdr with drug provocation test (DPT). The aim of this study was to examine the proportion of provocation-positive patients testing positive on IDTdr. Methods: Fifty-seven patients with a positive DPT occurring >2 h after intake of penicillin V, dicloxacillin, pivampicillin, or amoxicillin had an IDTdr with penicillin G, amoxicillin, ampicillin, and dicloxacillin. A control group included 18 patients with negative DPTs with the suspected penicillin. Results: In total 25% (n = 14) of provocation-positive patients tested positive on IDTdr. Among patients with positive IDTdr, 9/14 (64%) versus 11/43 (26%) in the IDTdr negative group (p < 0.05) had required oral steroids to treat skin reactions following DPT. No other differences between IDTdr positive and negative groups were found. No controls had a positive IDTdr. Conclusion: Investigating with IDTdr would have identified 25% of patients with a DPT-verified allergy with delayed reactions. It is difficult to target subgroups who will test positive on IDTdr. There were more patients who tested positive on IDT who had received oral steroids after DPT, and this may be an indication that skin reaction severity plays a role in skin testing diagnostics. Further potential predictors for positivity of IDTdr, such as duration of skin symptoms, should be assessed in large studies in order to optimize the investigations of nonimmediate drug allergic reactions.

01 Dec 2020·Journal of Cellular BiochemistryQ3 · BIOLOGY

Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer

Q3 · BIOLOGY

Article

Author: Zhang, Zhen ; Li, Yalun ; Wang, Yilin ; Xu, Dongping ; Wu, Yutong ; Hu, Xiaoyun ; Chen, Qiuchen ; Fu, Dandan ; Wei, Minjie ; Fu, Boshi ; Zhang, Jing ; Sun, Tong ; Lu, Senxu ; Wang, Xiufang ; Wu, Huizhe ; Wu, Zhikun ; Qin, Wenyan ; Zhao, Lin

AbstractCircular RNA (circRNA) has been reported to have great scientific significance and clinical value in multiple cancers including colorectal cancer (CRC). However, the biological function of most circRNAs in CRC is still in its infancy. Herein, we discovered the differential expressed circRNAs (DECs) between CRC tissues and matched adjacent using deep RNA sequencing and further confirmed the DECs expression by combining with another Gene Expression Omnibus dataset. Furthermore, we validated the expression of the top four upregulated circRNAs (hsa_circ_0030632, hsa_circ_0004887, hsa_circ_0001550, and hsa_circ_0001681) in both of paired CRC tissues and CRC cell lines. Then, a circRNA/microRNA/messenger RNA regulatory network was established and the Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed these four circRNAs participated in various biological processed including apoptotic process and multiple metabolic processes. Moreover, based on the regulatory network, three bioactive compounds (pergolide, pivampicillin, and methylergometrine) for the treatment of CRC were also found. In conclusion, this study improved our understanding of circRNAs and may also facilitate the finding of promising targets and biomarkers in CRC.

100 Deals associated with Pivampicillin

External Link

KEGG	Wiki	ATC	Drug Bank
D08396	Pivampicillin	J01CA02	DB01604

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Gonorrhea	-	-	-

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