Last update 14 Feb 2026

NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)

Overview

Basic Info

Drug Type
TCR-T Cell therapy
Synonyms-
Target
NY-ESO-1 x TGFB receptor
Action
modulators
Mechanism
NY-ESO-1 modulators(Cancer/testis antigen 1 modulators), TGF beta receptor modulators
Therapeutic Areas
NeoplasmsEndocrinology and Metabolic DiseaseUrogenital Diseases
Active Indication
Advanced Malignant Solid NeoplasmRecurrent ovarian cancer
Inactive Indication-
Originator Organization
The University of ChicagoThe University of Chicago
Active Organization
The University of ChicagoThe University of Chicago
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)
NCT07389239
/ Not yet recruitingPhase 1/2IIT
A Phase I/IIA Study Evaluating the Safety and Efficacy of NY-ESO-1TCR/dnTGFBRII Engineered T Cells in Combination With Decitabine in Subjects With Recurrent or Treatment Refractory Ovarian Cancer and Other Advanced Malignancies
100 Clinical Results associated with NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)
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100 Translational Medicine associated with NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)
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100 Patents (Medical) associated with NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)
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100 Deals associated with NY-ESO-1TCR/dnTGFBRII Engineered T Cells (The University of Chicago)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
United States
The University of ChicagoThe University of Chicago
23 Jun 2026
Recurrent ovarian cancerPhase 2
United States
The University of ChicagoThe University of Chicago
23 Jun 2026
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Clinical Trial

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Approval

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Regulation

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