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Last update 20 Mar 2025

Mesterolone

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Mesterolone (USAN/INN)

+ [1]

Target

Action

agonists

Mechanism

AR agonists(Androgen Receptor agonists)

Therapeutic Areas

Urogenital Diseases

Active Indication

Infertility

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC20H32O2

InChIKeyUXYRZJKIQKRJCF-TZPFWLJSSA-N

CAS Registry1424-00-6

100 Clinical Results associated with Mesterolone

100 Translational Medicine associated with Mesterolone

100 Patents (Medical) associated with Mesterolone

467

Literatures (Medical) associated with Mesterolone

01 Dec 2024·Drug Testing and Analysis

Interest of hair tests to discriminate a tail end of a doping regimen from a drug transfer between two individuals in case of challenging an anti‐doping rule violation. IV. Case example with mesterolone

Letter

Author: Kintz, Pascal ; Gheddar, Laurie

01 Nov 2024·Aquaculture

Effects of mesterolone on the sex ratio, physiology and liver function of juvenile tambaqui (Colossoma macropomum)

Author: de Souza de Oliveira, Rosilane G. ; Almeida O'Sullivan, Fernanda L. ; Morais, Irani Silva de ; Reis, Vanessa R. ; de Souza, Gabriela B. ; Tomas Jeronimo, Gabriela ; Almeida O′Sullivan, Fernanda L. ; C. Amaral, Aldessandro

In fish, sex dimorphism generates benefits for farming when one gender displays better production traits than the other.In such cases, farming exclusively one sex becomes more profitable.The tambaqui (Colossoma macropomum) is the Brazilian native species with the highest production in the Brazilian fish industry.In tambaqui farming, it is more lucrative to produce females because they grow faster than males.As the species has the XX/XY genetic sex determination system, the use of XX neomales (masculinized genetic females) as breeders to produce solely all-female populations is the most sustainable approach.With the aim of obtaining tambaqui neomales, we tested three doses of mesterolone (1-α-methylandrosterone; at 10, 20 and 40 mg kg^-1) through the diet of pre-differentiated juveniles for three months, to masculinize the females.The sex ratio and immediate and long-term effects on the physiol. of the fish were evaluated by hematol. and biochem. analyses of the blood plasma at the end of the treatment, and three months later.Possible hepatotoxic and mutagenic effects of mesterolone were assessed via liver histopathol., hepatic enzyme production and the micronucleus test (fragmented DNA) in the erythrocytes.The results indicate that 20 and 40 mg kg^-1 of mesterolone produced over 76% phenotypic males, have no influence on growth and on the biochem. parameters, do not cause DNA damage, nor do they have toxic effects in the liver of tambaqui.A decrease in the hepatosomatic index and an increase in some hematol. parameters were observed during the treatment, but all values were similar to the control three months after the end of the experiment

01 Sep 2024·Journal of Proteomics

Lipid metabolites abnormally expressed in pelvic fluid as potential biomarkers for ovarian cancer: A case-control study

Article

Author: Zhu, Yunshan ; Tang, Rongrong ; Zheng, Limei ; Ma, Xudong ; Chen, Lingfeng ; Sun, Fangying ; Tong, Jinfei ; Yang, Jianhua ; Yu, Hailan

BACKGROUNDOvarian cancer is insidious and usually detected in advanced stages of the disease. As the ovaries are pelvic organs, changes in their pelvic fluid metabolites may be associated with ovarian cancer.METHODSMetabolomic changes in the pelvic fluid were detected using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in patients with ovarian cancer, ovarian cysts and uterine fibroids. Area under the curve (AUC) analysis was used to assess the diagnostic performance of lipid metabolites and blood tumor indices. The Pearson correlation algorithm was used to analyze the correlation between clinical characteristics and lipid metabolites in ovarian cancer patients.RESULTSThere were 24 lipid metabolites significantly changed in the pelvic fluid of ovarian cancer patients (p < 0.05). Palmitoylcarnitine, lipoamide, lipid metabolites, and blood tumor indices (CA15-3 and CA125) showed AUC > 0.8, with palmitoylcarnitine reaching a high of 0.942. In addition, we found that some lipid metabolites were significantly associated with the clinical stage, abdominal water volume, lymphatic metastasis, and recurrence (p < 0.05, r > 0.5).CONCLUSIONLevels of specific lipid metabolites are potential biomarkers of ovarian cancer and may play a key role in the early diagnosis and prognostic assessment of ovarian cancer.SIGNIFICANCEOur results showed that pelvic metabolites, especially some lipid metabolites, play an important role in the diagnosis of ovarian cancer. Meanwhile, partial lipid metabolites were closely associated with the clinical presentation and prognosis of patients with ovarian cancer. We believe that our study makes a significant contribution to the literature because it provides a potential approach that is more effective for ovarian cancer detection.

100 Deals associated with Mesterolone

External Link

KEGG	Wiki	ATC	Drug Bank
D04947	Mesterolone	G03BB01	DB13587

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Infertility	-	-	-

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