Cyclandelate

An enamine-mediated photoredox catalyzed C(sp²)-C(sp³) cross-coupling of dual radical precursors for the arylation of ketone is presented in this Letter. These reactions led to the formation of an enamine by using pyrrolidine to functionalize the C(sp³)-H bond in ketone substrates, which could be smoothly converted to α-arylated ketones with inert aryl bromides and even aryl chlorides in moderate to good yields under mild reaction conditions. The photocatalytically induced C(sp²)-C(sp³) cross-coupling between unactivated noncyclic ketones and aryl halides was achieved, and multiple carbonyl α-arylated backbones containing various natural products and drug molecules were successfully constructed.

The presence of multidrug resistant bacteria in Malaysian waters and farmed aquatic species at its estuarine environment suggests pharmaceutical and personal care products (PPCPs) contamination.Despite this, this issue has lacked serious attention.This study performed suspect screening to identify tentative PPCPs in water and mussels located at the Melayu River during high and low tides, followed by a public awareness survey to understand the public behavior in handling PPCPs.In total, 75 PPCPs were tentatively identified.Four and six compounds were found in surface water during low and high tides, resp., while mussel samples showed 50 compounds during low tide and 35 compounds during high tide.Interestingly, 7 pharmaceuticals and 4 personal care products appeared in both tides in mussel samples.Survey findings revealed that while respondents understood PPCPs pathways entering the environment and associated threats, they were unaware of relevant laws and proper disposal methods for unused pharmaceuticals, which are often discarded together with domestic wastes.The findings highlight the urgent need for a detailed suspect screening with targeted anal. in order to establish relevant regulatory measures apart from providing public education on proper disposal of PPCPs to mitigate contamination.