Delving into the Latest Updates on COVID-2019 vaccine(Vyriad) with Synapse

Overview

Basic Info

Drug Type

Synthetic peptide vaccine, Prophylactic vaccine

Synonyms

VSV based covid 2019 vaccine, VSV SARS 2 (+G) vaccine, VSV-SARS-2 vaccine

Target

SARS-CoV-2 S protein

Action

inhibitors

Mechanism

SARS-CoV-2 S protein inhibitors(SARS-CoV-2 S protein inhibitors)

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication-

Inactive Indication

COVID-19

Originator Organization

Vyriad, Inc.

Active Organization-

Inactive Organization

Vyriad, Inc.

License Organization-

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Author: Lukkana Suksanpaisan ; Luke Russell ; Timothy Carey ; Nandakumar Packiriswamy ; Mulu Tesfay ; Kah-Whye Peng ; Patrycja Lech ; Stephen J. Russell ; Christopher Ziegler ; Samantha Reiter ; Miguel Á. Muñoz-Alía ; Toshie Sakuma ; Christopher D. Petro ; Rachael M. Lee ; Lianwen Zhang ; Michelle Haselton ; Scott Waniger ; Riya Narjari ; Karina Krotova ; Rianna Vandergaast ; Alina Baum ; Jody L. Janecek ; Baskar Balakrishnan ; Melanie L. Graham ; Kara Sevola ; Clement Gnanadurai ; Sabarinathan Ramachandran ; Chase Lathrum ; Jordan Recker ; Christos A. Kyratsous

An orally active vaccine capable of boosting SARS-CoV-2 immune responses in previously infected or vaccinated individuals would help efforts to achieve and sustain herd immunity. Unlike mRNA-loaded lipid nanoparticles and recombinant replication-defective adenoviruses, replicating vesicular stomatitis viruses with SARS-CoV-2 spike glycoproteins (VSV-SARS2) were poorly immunogenic after intramuscular administration in clinical trials. Here, by G protein trans-complementation, we generated VSV-SARS2(+G) virions with expanded target cell tropism. Compared to parental VSV-SARS2, G-supplemented viruses were orally active in virus-naive and vaccine-primed cynomolgus macaques, powerfully boosting SARS-CoV-2 neutralizing antibody titers. Clinical testing of this oral VSV-SARS2(+G) vaccine is planned.

100 Deals associated with COVID-2019 vaccine(Vyriad)

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