Delving into the Latest Updates on Hydroxyzine Pamoate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Hydroxyzine pamoate (JP17/USP), Atarax-P, Vistaril pamoate

+ [1]

Target

H1 receptor

Action

antagonists

Mechanism

H1 receptor antagonists(Histamine H1 receptor antagonists)

Therapeutic Areas

Immune System DiseasesNervous System DiseasesSkin and Musculoskeletal Diseases+ [1]

Active Indication

Anxiety DisordersCatatoniaChronic Urticaria+ [7]

Inactive Indication-

Originator Organization

Pfizer Inc.

Active Organization

Pfizer Laboratories (Pty) Ltd.

Pfizer Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (30 Sep 1965),

DermatitisEczemaNeurotic Disorders+ [2]

Regulation-

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Structure/Sequence

Molecular FormulaC21H27ClN2O2

InChIKeyZQDWXGKKHFNSQK-UHFFFAOYSA-N

CAS Registry68-88-2

View All Structures (2)

Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children. When the literature is examined, it is seen that different sedative drugs (benzodiazepines, barbiturates, phenothiazine, chloral hydrate, hydroxyzine, melatonin, etc.) and their combinations are used to provide sedation during EEG recordings, but there is no ideal sedative drug. Nurses working in the field of pediatric neurology in EEG recordings; It has important roles in preparing the child and parent for the procedure, applying sedation before the procedure, performing the EEG recording properly, monitoring vital signs during the procedure, monitoring the effects of the sedative substance after the procedure, and sending the patient home safely. Pediatric nurses fulfill these roles by adopting a multidisciplinary team approach. In this context, the aim of our research is; The aim of this study is to evaluate the effects of chloral hydrate, hydroxyzine and melatonin, which are used as sedative agents before EEG recording in children, on sleep success, time to fall asleep, side effects and EEG background.

Start Date01 Jan 2021

Sponsor / Collaborator

Suleyman Demirel University

100 Clinical Results associated with Hydroxyzine Pamoate

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100 Translational Medicine associated with Hydroxyzine Pamoate

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100 Patents (Medical) associated with Hydroxyzine Pamoate

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1,669

Literatures (Medical) associated with Hydroxyzine Pamoate

01 Mar 2025·Food Chemistry

Unraveling key non-volatiles responsible for taste differences of Pixian broad bean paste based on sensory analysis and untargeted metabolomics

Article

Author: Wei, Yilan ; Zhou, Wenjing ; Liu, Ping ; Yang, Aiping ; Xu, Min ; Xiang, Qin

Besides aroma, the tastes of Pixian Broad Bean Paste (PBBP) are also important, however, they have not yet been thoroughly elucidated. Therefore, this study employed sensory and untargeted metabolomics approaches to investigate taste characteristics, molecular basis and their metabolic pathways of PBBP from three different manufacturers and two grades. Results showed PBBP was predominantly characterized by strong sour, umami and salty tastes, and significant differences were observed in samples from different manufacturers and grades (p < 0.05), especially higher sourness, saltiness and umami in premium PBBP. Based on non-volatiles, 55 key differential metabolites were identified through orthogonal partial least square discriminant analysis (OPLS-DA, P value<0.05, VIP value>1.0) and Pearson correlation analysis (|ρ| > 0.7). These key differential metabolites responsible for taste differences were metabolized by 36 crucial KEGG pathways (P value<0.05, impact value>0.05). These results could expand our understandings of PBBP taste compounds and their metabolisms, and provide theoretical evidences for further quality improvement.

01 Jan 2025·Talanta

Buffer-free high pH mobile phase LC-MS/MS for determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 20 drugs and metabolites in whole blood

Article

Author: Maria, Marisa H ; Maria, Marisa H. ; Jørgenrud, Benedicte ; Nilsson, Galina ; McQuade, Tao ; Berg, Thomas

BACKGROUNDAcidic mobile phases are commonly used in reversed phase liquid chromatography tandem mass spectrometry (LC-MS/MS) bioanalysis. However, increased sensitivity, improved peak symmetry, and increased retention, especially for basic hydrophilic drugs have been observed using basic mobile phases. In our previous acidic mobile phase LC-MS/MS method we needed two injections (0.4 and 2.0 μL) of each sample for this task, which is inefficient. The aim of this study was to investigate if basic mobile phase LC-MS/MS could be used to determine phosphatidylethanol 16:0/18:1 and 20 other drugs and metabolites with satisfactory sensitivity in one single run.METHODSWhole blood was prepared by 96-well supported-liquid extraction using heptane/ethyl acetate/2-propanol (16:64:20, v:v:v). Chromatographic separation was achieved on an Acquity BEH C₁₈ column (50 × 2.1 mm I.D.), using a mobile phase with 0.025 % ammonia, pH 10.7 (Solvent A) and methanol (Solvent B). All compounds had isotope-labelled internal standards.RESULTSThe method was fully validated. Recovery was between 63 and 91 % for 20 compounds and 10 % for benzoylecgonine. Matrix effects were low, except for ion enhancement of buprenorphine and ion suppression for THC. However, internal standards compensated for these effects. Inter-assay precision and accuracy were < ± 20 % for all compounds at five tested concentrations, except for methamphetamine at the highest concentration.CONCLUSIONAn LC-MS/MS method for simultaneous determination of PEth 16:0/18:1 and 20 drugs and metabolites in whole blood were for the first time developed and validated. Retention of PEth 16:0/18:1 was, in contrast to the other 20 compounds, largely affected by mobile phase buffer concentration. The buffer free basic mobile phase ensured that phosphatidylethanol 16:0/18:1 eluted before most of the unwanted phospholipids.

31 Dec 2024·Annals of Medicine

Psychotherapeutic and pharmacological agents for post-traumatic stress disorder with sleep disorder: network meta-analysis

Review

Author: Zhang, Chao ; Zhao, Yi-Fan ; Liu, Run-Ben ; Liu, Jia-Ling ; Huang, Cheng-Yang ; Zhang, Zhi-Xin ; Li, Xiao-Zheng ; Luo, Jie ; Yue, Li

OBJECTIVEThe current guidelines and canonical norms of diagnosis or treatment for Post-traumatic stress disorder (PTSD) with sleep disorder are still conflicting and have not yet reached a consensus. This study aimed to unravel the most effective countermeasures between two categories (psychotherapy and pharmacotherapy) put forward by the National Institute for Health and Clinical Excellence (NICE) and World Federation of Societies of Biological Psychiatry (WFSBP) respectively to treat PTSD individuals co-exist with sleep disorders.METHODSFour databases, including PubMed, EMBASE, Cochrane Library, and APA PsyNet, were searched from inception to February 02, 2023.RESULTSTwenty articles with 24 Randomized controlled trials (RCTs) and a total number of 1,647 participants were included. As demonstrated in the network meta-analysis comparison results, CBT-I (standardized mean differences (SMD) = -1.51,95% confidence interval (CI):-2.55 to -0.47), CBT-I plus IRT (SMD = -1.71, 95%CI:-3.39, -0.03), prazosin (SMD = -0.87,95%CI:-1.59 to -0.16) and hydroxyzine (SMD = -1.06, 95%CI: -1.94 to -0.19) significantly reduced PTSD symptoms compared with placebo. In contrast to placebo, CBT-I (SMD = -5.61,95%CI:-8.82 to -2.40) significantly improved sleep quality. For nightmare severity, IRT (SMD =-0.65, 95%CI:-1.00 to -0.31), prazosin (SMD = -1.20,95%CI:-1.72 to -0.67) and hydroxyzine (SMD = -0.98,95%CI:-1.58 to -0.37) significantly reduced nightmare severity in comparison with placebo.CONCLUSIONSThis study suggested that under most circumstances, psychotherapy namely CBT-I had a favorable profile, but pharmacotherapy with prazosin was effective in managing nightmare severity. The sole avail of CBT-I was recommended to improving sleep quality while CBT-I and CBT-I plus IRT showed excellent management of PTSD symptom severity. Exposure to CBT-I isrecommended for depression. The relevant clinical guidelines for the management of individuals with PTSD and sleep disorders may regard this as a reference.PROSPEROCRD42023415240.

100 Deals associated with Hydroxyzine Pamoate

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External Link

KEGG	Wiki	ATC	Drug Bank
D01096	Hydroxyzine Pamoate	N05BB01	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anxiety Disorders	United States	Pfizer Laboratories (Pty) Ltd.	15 Nov 1968
Catatonia	United States	Pfizer Laboratories (Pty) Ltd.	15 Nov 1968
Chronic Urticaria	United States	Pfizer Laboratories (Pty) Ltd.	15 Nov 1968
Dermatitis, Contact	United States	Pfizer Laboratories (Pty) Ltd.	15 Nov 1968
Hypersensitivity	United States	Pfizer Laboratories (Pty) Ltd.	15 Nov 1968
Dermatitis	Japan	Pfizer Inc.	30 Sep 1965
Eczema	Japan	Pfizer Inc.	30 Sep 1965
Neurotic Disorders	Japan	Pfizer Inc.	30 Sep 1965
Pruritus	Japan	Pfizer Inc.	30 Sep 1965
Urticaria	Japan	Pfizer Inc.	30 Sep 1965