Last update 08 May 2025

MS159N2

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
Target
IKZF1 x IKZF3 x NSD2
Action
inhibitors
Mechanism
IKZF1 inhibitors(DNA-binding protein Ikaros inhibitors), IKZF3 inhibitors(Zinc finger protein Aiolos inhibitors), NSD2 inhibitors(nuclear receptor binding SET domain protein 2 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesCardiovascular Diseases+ [1]
Active Indication
Multiple Myeloma
Inactive Indication-
Originator Organization
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai
Active Organization
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC43H42N8O10
InChIKeyVTGRUIVPTAQSPY-UHFFFAOYSA-N
CAS Registry3036253-83-2

Related

100 Clinical Results associated with MS159N2
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100 Translational Medicine associated with MS159N2
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100 Patents (Medical) associated with MS159N2
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1
Literatures (Medical) associated with MS159N2
11 Aug 2022Journal of Medicinal ChemistryQ1 · MEDICINE
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos
Q1 · MEDICINE
100 Deals associated with MS159N2
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Multiple MyelomaPreclinical
United States
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai
27 Jul 2022
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Clinical Trial

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Approval

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Regulation

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