Last update 24 Mar 2025

SIAIS213110

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
SIAIS213110
Target
BRD2 x BRD3 x BRD4
Action
inhibitors, degraders
Mechanism
BRD2 inhibitors(Bromodomain-containing protein 2 inhibitors), BRD3 inhibitors(Bromodomain-containing protein 3 inhibitors), BRD4 degraders(Bromodomain-containing protein 4 degraders)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Neoplasms
Originator Organization
Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesShanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Active Organization-
Inactive Organization
Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesShanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Drug Highest PhasePendingPreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC37H39ClN8O4S
InChIKeyUYBVSBAZZWUPHH-XLTVJXRZSA-N
CAS Registry1883863-65-7

Related

100 Clinical Results associated with SIAIS213110
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100 Translational Medicine associated with SIAIS213110
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100 Patents (Medical) associated with SIAIS213110
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2
Literatures (Medical) associated with SIAIS213110
17 May 2019Organic lettersQ1 · CHEMISTRY
Chemoselective Synthesis of Lenalidomide-Based PROTAC Library Using Alkylation Reaction
Q1 · CHEMISTRY
Chemical communications (Cambridge, England)
Reactive oxygen species-responsive Pre-PROTAC for tumor-specific protein degradation
100 Deals associated with SIAIS213110
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPreclinical
China
Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesShanghai Institute of Organic Chemistry, Chinese Academy of Sciences
08 May 2019
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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