Last update 28 May 2025

PF-06940434

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
PF 06940434
Target
CD51 x αvβ8
Action
antagonists, inhibitors
Mechanism
CD51 antagonists(Integrin alpha-V antagonists), αvβ8 inhibitors(Integrin αvβ8 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmMetastatic Solid Tumor
Inactive Indication
Bile Duct NeoplasmsEndometrial CarcinomaEsophageal Carcinoma+ [8]
Originator Organization
Pfizer Inc.Pfizer Inc.
Active Organization
Pfizer Inc.Pfizer Inc.
Inactive Organization-
License Organization-
Drug Highest PhaseIND Approval
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with PF-06940434
NCT04152018
/ TerminatedPhase 1
A PHASE 1 STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF ESCALATING DOSES OF PF-06940434 IN PATIENTS WITH ADVANCED OR METASTATIC SOLID TUMORS
100 Clinical Results associated with PF-06940434
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100 Translational Medicine associated with PF-06940434
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100 Patents (Medical) associated with PF-06940434
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100 Deals associated with PF-06940434
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bile Duct NeoplasmsPhase 1
United States
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Bile Duct NeoplasmsPhase 1
Australia
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Bile Duct NeoplasmsPhase 1
Slovakia
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Bile Duct NeoplasmsPhase 1
Taiwan Province
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Endometrial CarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Endometrial CarcinomaPhase 1
Australia
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Endometrial CarcinomaPhase 1
Slovakia
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Endometrial CarcinomaPhase 1
Taiwan Province
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Esophageal CarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
13 Nov 2019
Esophageal CarcinomaPhase 1
Australia
Pfizer Inc.Pfizer Inc.
13 Nov 2019
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Clinical Result

Indication
Phase
Evaluation
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Phase
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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