Fozivudine tidoxil

The antibiotic resistance rate of Helicobacter pylori (H. pylori) has increased year by year with the widespread use of antibiotics, resulting in reduced efficacy of eradication therapy and increased recurrence rate. We conducted a survey on H. pylori resistance in the South area of Sichuan province to provide guidance for front-line treatments of H. pylori in this area.

Helicobacter pylori strains were isolated from gastric mucosa specimens obtained from patients with suspected H. pylori infection from the South area of Sichuan province. Antibiotic susceptibility of the strains was determined by disk diffusion method.

Among 373 patients, 323 were from southern Sichuan. H. pylori strains were isolated and cultured from gastric mucosa samples of 304 patients, resulting in an isolation and culture success rate of 81.50%. Metronidazole (MNZ) is the antibiotic with the highest drug resistance rate in the South area of Sichuan province, with a drug resistance rate as high as 98.68%. The resistance rates of amoxicillin and furazolidone were very low, accounting for 0.29% and 0.99%, respectively. However, tetracycline showed no resistance. Single antibiotic resistance accounted for 35.67%, while the resistance to 2 antibiotics was dual resistance, accounting for 34.67%. Dual drug resistance was mainly MNZ and levofloxacin, followed by MNZ and clarithromycin (CLA).

MNZ, levofloxacin, and CLA should be used cautiously in H. pylori eradication therapy in the South area of Sichuan province. If the cultivation results and drug sensitivity test results of the H. pylori strain cannot be obtained, it is recommended to adopt an empirical treatment plan, using the pairwise combinations of amoxicillin, tetracycline, and FZD, especially the combination of amoxicillin and tetracycline.

Furazolidone (FZD), a nitrofuran antibiotic used for the treatment of bacterial and protozoal illnesses, generates apprehensions about its potential toxicity and mutagenicity. The swift and dependable identification of FZD in food and biological specimens is essential for public health and regulatory adherence. This study presents a novel electrochemical sensor using a glassy carbon electrode (GCE) modified with a cobalt-based metal-organic framework (Co-MOF) and carbon black (CB) composite (Co-MOF@CB/GCE) for the sensitive detection of FZD. The Co-MOF@CB composite enhances electron transport and expands the electroactive surface area. Characterization investigations confirmed the successful fabrication of the Co-MOF@CB/GCE sensor. Electrochemical analyses revealed an extensive detection range (0.4-610 μmolL^-1) and a minimal detection limit (0.0875 μmolL^-1). The sensor exhibited great repeatability, stability, and selectivity, demonstrating efficient FZD detection in milk, honey, and chicken. This sensor provides a reliable, economical tool for FZD detection in regulatory and public health contexts.