Delving into the Latest Updates on Fozivudine tidoxil with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Fozivudine, FZT, BM 21.1290

+ [8]

Target

RT

Action

inhibitors

Mechanism

RT inhibitors(Viral reverse transcriptase inhibitors)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesUrogenital Diseases

Active Indication-

Inactive Indication

HIV Infections

Originator Organization

Heidelberg Pharma AG

Active Organization-

Inactive Organization

Ludwig-Maximilians-Universität München

Heidelberg Pharma AG

License Organization-

Drug Highest PhasePendingPhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC35H64N5O8PS

InChIKeyIBHARWXWOCPXCR-WELGVCPWSA-N

CAS Registry141790-23-0

A Prospective, Multicenter, Open, Randomized Phase 2a Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen After 24 Weeks of Treatment in ART naïve, Non Subtype B HIV-1 Infected Individuals From Tanzania and Ivory Coast

A prospective, multicenter, open, randomized Phase 2a trial to confirm a sustained virological suppression defined as HIV-RNA <50 copies/ml of 3 different doses of Fozivudine in context to a standard Zidovudine based antiretroviral therapy regimen after 24 weeks of treatment in ART naïve, non subtype B HIV-1 infected individuals from Tanzania and Ivory Coast.

Start Date01 Dec 2012

Sponsor / Collaborator

Ludwig-Maximilians-Universität München

[+5]

PACTR201205000384379

/ CompletedPhase 2IIT

A Prospective, Multicenter, Open, Randomized Phase 2a Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen After 24 Weeks of Treatment in ART naïve, Non Subtype B HIV-1 Infected Individuals From Tanzania and Ivory Coast

Start Date01 Aug 2012

Sponsor / Collaborator-

NCT00002385

/ CompletedNot Applicable

Multicenter, Rising, Multiple-Dose, Placebo-Controlled, Dose-Response Study to Evaluate the Safety, Tolerability, and Anti-Viral Activity of 4 Weeks of Treatment With 200-800 Mg Fozivudine Tidoxil in Patients With HIV-1 Infection (MF4314).

To identify doses of fozivudine tidoxil that are well tolerated and produce measurable antiviral activity.
To identify the adverse event profile that defines the maximum tolerated dose. To characterize the single- and multiple-dose pharmacokinetics of fozivudine and its metabolites.
To correlate the adverse event profile and antiviral activity of fozivudine with pharmacokinetic parameters.

Start Date-

Sponsor / Collaborator

Anderson Clinical Research

[+1]

100 Clinical Results associated with Fozivudine tidoxil

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100 Translational Medicine associated with Fozivudine tidoxil

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100 Patents (Medical) associated with Fozivudine tidoxil

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59

Literatures (Medical) associated with Fozivudine tidoxil

09 Mar 2026·INORGANIC CHEMISTRY

Lanthanide metal–organic Framework Fluorescent Sensor for the Detection of Furazolidone in Tap Water and Animal Feed

Article

Author: Yang, Wei-Ting ; Su, Zhong-Min ; Xiao, Meng-Dan ; Ye, Jin-Ting ; Wang, Lu-Yao ; Lin, Yuan ; Chen, Shu-Yu ; Liu, Yan-Feng ; Gong, Ya-Ru

The illegal use of furazolidone (FZD) in livestock and aquaculture results in FZD residues in related products, posing significant health risks such as carcinogenicity and teratogenicity. Accordingly, there is an urgent necessity to develop advanced analytical sensors for the detection of FZD residues. In this study, a Ln-MOF fluorescent sensor (HNU-104) was fabricated for the rapid detection of FZD, and it maintains structural stability in solutions with pH values ranging from 3 to 11. The limit of detection (LOD) for the FZD was found to be 37.3 ppb. For the analysis of actual samples, the spiked recovery rate ranged from 95.76% to 108.62%, and the relative standard deviation (RSD) was less than 0.10%. Furthermore, the sensing mechanism study indicates that fluorescence quenching is caused by the synergistic effects of the inner filter effect (IFE) and photoinduced electron transfer (PET). This work provides a robust Ln-MOF-based platform for the rapid and highly selective detection of FZD, showing great potential for applications in food safety analysis.

20 Nov 2025·JOURNAL OF INFECTIOUS DISEASES

Follow-up and Analysis of Helicobacter pylori Antibioic Resistance in the South Area of Sichuan Province

Article

Author: Li, Changping ; Li, Ying ; Xu, Mei ; Liang, Chunhong ; Zhou, Yuyang

Abstract:

Background:

The antibiotic resistance rate of Helicobacter pylori (H. pylori) has increased year by year with the widespread use of antibiotics, resulting in reduced efficacy of eradication therapy and increased recurrence rate. We conducted a survey on H. pylori resistance in the South area of Sichuan province to provide guidance for front-line treatments of H. pylori in this area.

Methods:

Helicobacter pylori strains were isolated from gastric mucosa specimens obtained from patients with suspected H. pylori infection from the South area of Sichuan province. Antibiotic susceptibility of the strains was determined by disk diffusion method.

Results:

Among 373 patients, 323 were from southern Sichuan. H. pylori strains were isolated and cultured from gastric mucosa samples of 304 patients, resulting in an isolation and culture success rate of 81.50%. Metronidazole (MNZ) is the antibiotic with the highest drug resistance rate in the South area of Sichuan province, with a drug resistance rate as high as 98.68%. The resistance rates of amoxicillin and furazolidone were very low, accounting for 0.29% and 0.99%, respectively. However, tetracycline showed no resistance. Single antibiotic resistance accounted for 35.67%, while the resistance to 2 antibiotics was dual resistance, accounting for 34.67%. Dual drug resistance was mainly MNZ and levofloxacin, followed by MNZ and clarithromycin (CLA).

Conclusions:

MNZ, levofloxacin, and CLA should be used cautiously in H. pylori eradication therapy in the South area of Sichuan province. If the cultivation results and drug sensitivity test results of the H. pylori strain cannot be obtained, it is recommended to adopt an empirical treatment plan, using the pairwise combinations of amoxicillin, tetracycline, and FZD, especially the combination of amoxicillin and tetracycline.

20 Nov 2025·JOURNAL OF INFECTIOUS DISEASES

Antimicrobial Resistance of Helicobacter pylori Among Chinese Yi Population

Article

Author: Wang, Ying ; Song, Xiaona ; Feng, Ping ; Shen, Yalin ; Chen, Liyu ; Ma, Yufan ; Tang, Hong ; Ma, Siyan ; Zhang, Qin ; Li, Hong ; Marshall, Barry J ; Tay, Alfred C Y ; Ma, Fanghua ; Zhang, Jinzhi

Abstract:

Background:

Antibiotic resistance significantly impacts the success of Helicobacter pylori eradication. This study aimed to evaluate the antibiotic resistance patterns among a Chinese Yi ethnic population.

Methods:

Gastric biopsy specimens were collected from Chinese Yi patients undergoing endoscopy at 2 hospitals for H. pylori isolation and pathological assessment. Antimicrobial susceptibility testing (AST) was performed for amoxicillin (AML), tetracycline (TET), clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LEV), rifampicin (RIF), and furazolidone (FZD) using Etest or disk diffusion. Univariate and multivariate logistic analysis were used to identify factors associated with antimicrobial resistance.

Results:

From 501 gastric specimens, 262 H. pylori strains were isolated (52.3% culture rate). Of the 262 H. pylori-positive patients (110 men and 152 women, mean age 40.7 years), endoscopic findings revealed that 129 (49.2%) had chronic atrophic gastritis, 40 (15.3%) had peptic ulcers, and 2 (0.8%) had gastric malignancy. Pathological analysis revealed a high prevalence of moderate-to-severe chronic gastric atrophy (75.6%), intestinal metaplasia (14.7%), and dysplasia (0.8%). The overall resistance rates were the following: AML (0.0%), TET (0.4%), CLR (22.9%), MTZ (86.3%), LEV (39.7%), RIF (52.7%), and FZD (0.0%). Multi-drug resistance was observed in 32.1% of the strains. Age (for CLR, MTZ, and LEV) and female gender (for MTZ) were independent factors associated with antimicrobial resistance.

Conclusions:

Chronic gastric atrophy is highly prevalent among Yi patients, emphasizing the need for endoscopic screening and prompt H. pylori eradication to prevent gastric cancer. Due to high resistance, CLR, MTZ, and LEV should not be used empirically. In contrast, TET, AML, and FZD show negligible resistance, treatment regimens based on these antibiotics are likely to be effective.

100 Deals associated with Fozivudine tidoxil

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External Link

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R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
HIV Infections	Phase 2	Côte d'Ivoire	Ludwig-Maximilians-Universität München	01 Dec 2012
HIV Infections	Phase 2	Tanzania	Ludwig-Maximilians-Universität München	01 Dec 2012