[Translation] A randomized, double-blind, placebo-controlled, multicenter phase II clinical trial to evaluate the efficacy and safety of human interferon α2b spray in the treatment of herpetic pharyngitis in children

初步评估人干扰素α2b喷雾剂用于治疗儿童疱疹性咽峡炎的有效性和安全性，为III期临床试验设计和给药剂量方案的确定提供依据。

[Translation]

To preliminarily evaluate the efficacy and safety of human interferon α2b spray in the treatment of herpetic pharyngitis in children, and provide a basis for the design of Phase III clinical trials and the determination of dosing regimen.

Start Date25 May 2024

Sponsor / Collaborator

Anhui Anke Biotechnology (Group) Co., Ltd.

100 Clinical Results associated with Interferon alfa-2b(Anhui Anke Biotechnology (Group) Co., Ltd.)

100 Translational Medicine associated with Interferon alfa-2b(Anhui Anke Biotechnology (Group) Co., Ltd.)

100 Patents (Medical) associated with Interferon alfa-2b(Anhui Anke Biotechnology (Group) Co., Ltd.)

Literatures (Medical) associated with Interferon alfa-2b(Anhui Anke Biotechnology (Group) Co., Ltd.)

Anticancer research

Inhibition of human glioma cell proliferation and glutathione S-transferase by ascorbyl esters and interferon.

Article

Author: Kulkarni, A P ; Wiranowska, M ; Prockop, L D ; Naidu, A K ; Kori, S H

The in vitro effect of ascorbyl esters (ascorbyl-stearate [As-S] and -palmitate [As-P]) and interferon (recombinant human interferon-a2b [rHuIFN-a2b]) on human glioma (U-373) cell proliferation, viability and glutathione-S-transferase (GST) activity was studied. The effect of As-S, As-P and rHuIFN-a2b on cell proliferation and viability was evaluated by [3H] Thymidine incorporation and colorimetric MTT assays, respectively. Incubation of glioma cells with As-S, As-P or rHuIFN-a2b for 24 h resulted in a dose dependent inhibition of cell proliferation (IC50 = 68.0 microM As-S, 86.0 microM As-P and 47.3 Units/ml rHuIFN-a2b), and moderate decrease of cell viability. It was found that As-S was a more efficient inhibitor of cell proliferation, viability and GST activity than As-P. GST from U-373 cells was purified. The activity of purified GST towards 1-chloro-2,4-dinitrobenzene (CDNB) was inhibited in a dose dependent manner by ascorbyl esters (I-50 = 27.5 microM As-S and 56.0 microM As-P) but not by rHuIFN-a2b. GST activity of cytosol isolated from U-373 cells which were previously treated with As-S (150 microM) or rHuIFN-a2b (150 units/ml) for 0, 2, 5, 10, 20 and 30 min was sharply decreased during 5 to 10 min of treatment and increased at longer durations of treatment.

100 Deals associated with Interferon alfa-2b(Anhui Anke Biotechnology (Group) Co., Ltd.)

External Link

KEGG	Wiki	ATC	Drug Bank
D02745	-	L03AB05	-

R&D Status

Approved

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Indication	Country/Location	Organization	Date
Condylomata Acuminata	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Hairy Cell Leukemia	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Hepatitis B	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Hepatitis C	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Herpes Simplex	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Herpes Zoster	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Herpes Zoster Ophthalmicus	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Human Papillomavirus Infection	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Philadelphia chromosome positive chronic myelogenous leukemia	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997
Uterine Cervical Erosion	China	Anhui Anke Biotechnology (Group) Co., Ltd.	01 Jan 1997

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Herpangina	Phase 2	China	Anhui Anke Biotechnology (Group) Co., Ltd.	25 May 2024

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