Last update 05 Sep 2026

Methylsamidorphan chloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Methylsamidorphan, Methylsamidorphan chloride (USAN/INN), ALKS-37
+ [3]
Target
μ opioid receptor
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Therapeutic Areas
Nervous System DiseasesDigestive System DisordersOther Diseases
Active Indication-
Inactive Indication
Chronic PainOpioid-Induced Constipation
Originator Organization
Alkermes PlcAlkermes Plc
Active Organization-
Inactive Organization
Alkermes, Inc.
License Organization-
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC22H29ClN2O4
InChIKeyJUQZWTLIXTTXHP-DWXUHONMSA-N
CAS Registry1118885-67-8

Related

3
Clinical Trials associated with Methylsamidorphan chloride
NCT01418092
/ CompletedPhase 2
A Phase 2b Randomized, Double-blind, Placebo-controlled, 12-week Study to Evaluate the Safety and Efficacy of ALKS 37 in Subjects With Opioid-induced Constipation
NCT01382797
/ CompletedPhase 2
A Phase 2b Randomized, Double-blind, Placebo-controlled, Repeat-dose Study to Evaluate the Safety, Tolerability, and Efficacy of ALKS 37 in Subjects With Opioid-induced Constipation
NCT01100151
/ CompletedPhase 2
A Phase 2 Study of the Effects of RDC-1036 Administered to Subjects With Opioid-induced Constipation During Treatment With Opioids for Chronic Pain
100 Clinical Results associated with Methylsamidorphan chloride
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100 Translational Medicine associated with Methylsamidorphan chloride
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100 Patents (Medical) associated with Methylsamidorphan chloride
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100 Deals associated with Methylsamidorphan chloride
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External Link

KEGGWikiATCDrug Bank
D10648--
DB15241

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic PainPhase 2
United States
Alkermes, Inc.
01 Apr 2010
Opioid-Induced ConstipationPhase 2
United States
Alkermes, Inc.
01 Apr 2010
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Clinical Result

Indication
Phase
Evaluation
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Clinical Trial

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Approval

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Regulation

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