[Translation] A randomized, double-blind, placebo-controlled, dose-escalating phase I clinical study to evaluate the safety, tolerability and pharmacokinetic characteristics of a single oral dose of CY150112 tablets in healthy subjects
主要目的:评价健康受试者单次口服CY150112片的安全性和耐受性。
次要目的:
1.评价健康受试者单次口服CY150112片的药代谢动力学(PK)特性。
2.初步评价单次口服CY150112片对受试者QTc间期的影响。
3.鉴定CY150112的体内代谢产物并检测其丰度。
[Translation] Primary objective: To evaluate the safety and tolerability of a single oral administration of CY150112 tablets in healthy subjects.
Secondary objectives:
1. To evaluate the pharmacokinetic (PK) properties of a single oral administration of CY150112 tablets in healthy subjects.
2. To preliminarily evaluate the effect of a single oral administration of CY150112 tablets on the QTc interval of subjects.
3. To identify the in vivo metabolites of CY150112 and detect their abundance.