Delving into the Latest Updates on Moxisylyte Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Erecnos, Moxisylyte, Moxisylyte hydrochloride (JAN)

+ [4]

Target

ADRA1

Mechanism

ADRA1 antagonists(Adrenergic receptor alpha-1 antagonists)

Therapeutic Areas

Cardiovascular DiseasesUrogenital Diseases

Active Indication

Erectile DysfunctionPeripheral Vascular Diseases

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC16H26ClNO3

InChIKeyIPWGSXZCDPTDEH-UHFFFAOYSA-N

CAS Registry964-52-3

Although oral phosphodiesterase 5 inhibitors represent a first choice and long-term option for about half of all patients with erectile dysfunction (ED), self-injection therapy with vasoactive drugs remains a viable alternative for all those who are not reacting or cannot tolerate oral drug therapy. This current injection therapy has an interesting history beginning in 1982.

Objectives:

To provide a comprehensive history of self-injection therapy from the very beginnings in 1982 by contemporary witnesses and some members of the International Society for Sexual Medicine’s History Committee, a complete history of injection therapy is prepared from eyewitness accounts and review of the published literature on the subject, as well as an update of the current status of self-injection therapy.

Methods:

Published data on injection therapy, as a diagnostic and therapeutic tool for ED, were reviewed thoroughly by PubMed and Medline research from 1982 until June 2023. Early pioneers and witnesses added firsthand details to this historical review. Therapeutic reports of injection therapy were reviewed, and results of side effects and complications were thoroughly reviewed.

Results:

The pioneers of the first hours were Ronal Virag (1982) for papaverine, Giles Brindley (1983) for cavernosal alpha-blockade (phentolamine and phenoxybenzamine), Adrian Zorgniotti (1985) for papaverine/phentolamine, and Ganesan Adaikan and N. Ishii (1986) for prostaglandin E1. Moxisylyte (thymoxamine) was originally marketed but later withdrawn. The most common side effect is priapism, with the greatest risk of this from papaverine, which has modified its use for therapy. Currently, prostaglandin E1 and trimixes continue to be the agents of choice for diagnostic and therapeutic use in ED. A recent agent is a mixture of a vasoactive intestinal polypeptide (aviptadil) and phentolamine.

Conclusions:

After 40 years, self-injection therapy represents the medication with the highest efficacy and reliability rates and remains a viable option for many couples with ED. The history of this therapy is rich.

01 Dec 2022·Ecotoxicology (London, England)

Effects of adrenergic α-antagonists on the early life stages of Japanese medaka (Oryzias latipes)

Article

Author: He, Zepeng ; Qian, Baoliu ; Lin, Xia ; Wang, Haixia ; Sun, Liwei

The occurrence of pharmaceuticals in the aquatic environment has stimulated considerable research efforts into their potential ecotoxicological consequences. There are a number of pharmaceuticals targeting adrenergic receptors; however, relatively few studies have explored the effects of adrenergic α-antagonists (or α-blockers) on fish. In this study, moxisylyte was selected as a representative α-blocker, and Japanese medaka embryos were exposed to moxisylyte (1-625 μg/L) for 44 days. Moxisylyte caused no significant or only marginal effects on the mortality, development, and growth; however, most genes involved in detoxification and antioxidant were transcriptionally upregulated, and antioxidant enzymes activities were induced as well. Moxisylyte exposure resulted in transcriptional downregulation of most of the steroidogenesis genes, and accordingly, the mRNA levels of steroid hormone receptors and vitellogenin decreased, particularly in males, indicating that moxisylyte disrupts the hypothalamic-pituitary-gonadal (HPG) axis in a gender-specific manner. Therefore, the risk of α-blockers on fish should not be overlooked and deserves further investigation.

01 Nov 2015·Eye (London, England)Q3 · MEDICINE

Response to ‘Role of miotics and cycloplegics in angle closure’

Q3 · MEDICINE

Letter

Author: Kawali, A ; Puthuran, G V ; Vijayalakshmi, P ; Rajamani, M

A review.Sir, We sincerely thank Dr Gupta for his expert comments¹ on our article.².Urbanek had coined the term inverse glaucoma to describe the pupillary block caused by miotics.Miotics cause ciliary muscle contraction, slackening the zonules, causing forward movement of the crystalline lens, thus shallowing the anterior chamber and increasing the pupillary block.³.We have used miotics to prevent an anteriorly dislocated crystalline lens from falling back into the posterior chamber/vitreous before surgery.Ritch and Wand propose the use of thymoxamine after a peripheral iridotomy to prevent lens dislocation into the anterior chamber.Thymoxamine is an alpha adrenergic blocker that causes miosis by inhibiting sympathetic pupillary dilatation and does not affect the ciliary muscle.⁴.We do not have any personal experience with the use of thymoxamine and the drug for ocular use is not available in our country.Cycloplegic agents on the other hand relax the ciliary muscles, tighten zonular support thereby pushing the lens back and deepening the anterior chamber.⁴.As Dr Gupta D rightly points out, the effect of miotics and cycloplegics would depend on the zonular integrity that is difficult to predict.It has been our experience and that of others^4, ⁵ that the use of mydriatics is associated with a high incidence of lens dislocation in the anterior chamber.Cyclopentolate has been reported to produce bilateral angle closure glaucoma in a patient with Weill Marchesani syndrome.⁶.We believe that a laser peripheral iridotomy is a more reliable way to prevent pupillary block in microspherophakia and pharmacol. agents (miotics/mydriatics) may have a very limited role in the management of this condition.Caution is advised with their use.

100 Deals associated with Moxisylyte Hydrochloride

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