Delving into the Latest Updates on CG-0161 with Synapse

Overview

Basic Info

Drug Type

Monoclonal antibody

Synonyms

Target

CTLA4

Action

inhibitors

Mechanism

CTLA4 inhibitors(Cytotoxic T-Lymphocyte-Associated Antigen 4 inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

CG Oncolgy

Active Organization

CG Oncolgy

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Resins significantly improved the production of trichothecenes from Myrothecium by a method which may be useful for the production of antibiotics in submerged cultures.M. verrucaria CL-72 is a good producer of macrocyclic trichothecenes, particularly verrucarin A.The resins evaluated were the Amberlite resins XAD-4, XAD-7, XAD-8, and Amberchrom CG-71 and CG-161.The latter 2 are resins which are of a finer mesh size than the Amberlite resins.The resins were 1st evaluated for their ability to adsorb the trichothecenes from the aqueous fermentation broth.Both XAD-4 and CG-71 were relatively inefficient at adsorbing the more polar trichothecenes (e.g. <60% of roridin A and baccharinoid B4 were adsorbed by these resins), but performed satisfactorily with the less polar trichothecenes such as verrucarin J (>80% absorption from solution).The other resins, XAD-7, XAD-8, and CG-161 adsorbed >80% of the trichothecenes from the fermentation broths, though XAD-8 tended to be somewhat less efficient.Therefore, XAD-7 and CG-161 (chromatog. grade of XAD-7) were the resins of choice.

100 Deals associated with CG-0161

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	United States	CG Oncolgy	12 Aug 2022

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Clinical Result

Indication

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

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