Allylisopropylacetylurea (AIAU) is a hypnotic sedative and can cause severe fixed drug eruption (FDE).Here, we report a case in which AIAU and bromovalerylurea (bromisoval; BU) caused an FDE at the same site.He often took two antipyretic analgesics, mainly ibuprofen, to self-treat migraine attacks.One of these contained AIAU and the other contained BU.Because FDEs caused by AIAU are relatively well-known to dermatologists and allergists in Japan, we considered AIAU to be the causative allergen and performed a patch test.Therefore, FDEs caused by AIAU rather than BU might be reported more frequently.AIAU and BU are essentially unnecessary ingredients in head-ache medicines, and over-the-counter medicines should not contain them.

31 Jul 2023·The Journal of Biochemistry

The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2

Article

Author: Miyoshi, Shoko ; Motohashi, Hozumi ; Yano, Hajime ; Tanaka, Junya ; Takeda, Haruna ; Nagashio, Kodai ; Nakajima, Yoshihiro ; Sekine, Hiroki ; Watanabe, Itaru ; Yamaguchi, Teruaki

AbstractThe Kelch-like ECH-associated protein 1–nuclear factor erythroid 2-related factor 2 (KEAP1–NRF2) system plays a central role in redox homeostasis and inflammation control. Oxidative stress or electrophilic compounds promote NRF2 stabilization and transcriptional activity by negatively regulating its inhibitor, KEAP1. We have previously reported that bromovalerylurea (BU), originally developed as a hypnotic, exerts anti-inflammatory effects in various inflammatory disease models. However, the molecular mechanism underlying its effect remains uncertain. Herein, we found that by real-time multicolor luciferase assay using stable luciferase red3 (SLR3) and green-emitting emerald luciferase (ELuc), BU potentiates NRF2-dependent transcription in the human hepatoblastoma cell line HepG2 cells, which lasted for more than 60 h. Further analysis revealed that BU promotes NRF2 accumulation and the transcription of its downstream cytoprotective genes in the HepG2 and the murine microglial cell line BV2. Keap1 knockdown did not further enhance NRF2 activity, suggesting that BU upregulates NRF2 by targeting KEAP1. Knockdown of Nfe2l2 in BV2 cells diminished the suppressive effects of BU on the production of pro-inflammatory mediators, like nitric oxide (NO) and its synthase NOS2, indicating the involvement of NRF2 in the anti-inflammatory effects of BU. These data collectively suggest that BU could be repurposed as a novel NRF2 activator to control inflammation and oxidative stress.

01 Jan 2023·Biochemical and Biophysical Research Communications

Bromovalerylurea modulates GABAA receptor-mediated inhibitory neurotransmission while inducing sleep

Article

Author: Choudhury, Mohammed E ; Tanaka, Junya ; Yoshimura, Yumiko ; Sato, Arisa ; Yano, Hajime ; Takeda, Haruna ; Kihara, Nanako ; Takagi, Masahiro

Bromovalerylurea (BU), an acyl urea derivative, was originally developed as a hypnotic/sedative. We recently reported that BU at a dose of 50 mg/kg ameliorates sepsis, Parkinson's disease, and traumatic brain injury in Wistar rat models through its anti-inflammatory actions on microglia and macrophages. However, since BU was developed more than 100 years ago, its hypnotic mechanism and characteristics are poorly understood. Herein, we conducted an electroencephalogram (EEG) study and found that BU, when administered at a dose of more than 125 mg/kg but not at a dose of 50 mg/kg in Wistar rats, significantly increased non-rapid eye movement (NREM) sleep duration and dose-dependently decreased rapid eye movement (REM) sleep duration. This characteristic of sleep induced by BU is similar to the effect of compounds such as barbiturate, benzodiazepine, and z-drugs, all of which require γ-aminobutyric acid _A receptors (GABA_AR) for hypnotic/sedative activity. To investigate whether BU could potentiate GABA_Aergic neurotransmission, we conducted a whole-cell patch-clamp recording from pyramidal neurons in rat cortical slices to detect spontaneous GABA_AR-mediated inhibitory postsynaptic currents (IPSCs). We found that BU dose-dependently prolonged IPSCs. Importantly, the prolonged IPSCs were not attenuated by flumazenil, a benzodiazepine receptor antagonist, suggesting that modulation of IPSCs by BU is mediated by different mechanisms from that of benzodiazepine. Taken together, these data elucidate the basic characteristics of the hypnotic effects of BU and suggest that the enhancement of GABA_AR-mediated Cl^- flux may be a possible mechanism that contributes to its hypnotic/sedative activity.

100 Deals associated with Bromisoval

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KEGG	Wiki	ATC	Drug Bank
D01391	Bromisoval	N05CM03	DB13370

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Indication	Country/Location	Organization	Date
Anxiety Disorders	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	-
Sleep Initiation and Maintenance Disorders	CN	China Resources Double-Crane Pharmaceutical Co., Ltd.	-

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