Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav1.8 and Nav1.7 are essential for detecting pain induced by cold temperatures. This study aims to validate these findings in humans.

Start Date07 Jul 2023

Sponsor / Collaborator

Medical University of Vienna

NCT01812265 / CompletedPhase 1

A Double Blind (3rd Party Open), Randomized, Placebo Controlled, Crossover Study To Investigate The Effects Of Pf-06305591 On Cold Pain In Healthy Male Subjects

This study will evaluate the pharmacological activity of PF-06305591 in healthy male volunteers by assessing the effects of two dose levels of PF-06305591 on cold pain intensity evoked by keeping non-dominant hand into a water bath kept at 2+/- degrees.

Start Date01 Jun 2013

Sponsor / Collaborator

Pfizer Inc.

NCT01776619 / CompletedPhase 1

A Double Blind (3rd Party Open) Randomized, Dose Escalation Study to Investigate the Safety, Tolerability, Pharmacokinetics of Repeat Doses PF-06305591 Combined With a Cross-over Relative Bioavailability and Food Effect Evaluation After Single Dose of PF-06305591 in Healthy Young Subjects

Safety, tolerability and PK of repeated doses of PF-06305591 will be evaluated in young healthy volunteers toghether with food effect on relative bioavailability of solid formulation after single dose.

Start Date01 Apr 2013

Sponsor / Collaborator

Pfizer Inc.

100 Clinical Results associated with PF-6305591

100 Translational Medicine associated with PF-6305591

100 Patents (Medical) associated with PF-6305591

Literatures (Medical) associated with PF-6305591

01 Jan 2019·Bioorganic & medicinal chemistryQ3 · MEDICINE

The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain

Q3 · MEDICINE

Article

Author: Murata, Yoshihisa ; Blackwell, Paul ; Warmus, Joseph S ; Miller, Duncan ; Brown, Bruce ; Stevens, Edward B ; Blakemore, David C ; Bagal, Sharan K ; Klute, Wolfgang ; Malet Sanz, Laia ; Gray, Victoria ; Skerratt, Sarah ; Brown, Alan D ; Fengas, David ; Kemp, Mark ; Crawforth, James ; Fenwick, David R ; Payne, C Elizabeth ; Bungay, Peter J ; Corless, Martin

The voltage gated sodium channel Na_V1.8 has been postulated to play a key role in the transmission of pain signals. Core hopping from our previously reported phenylimidazole leads has allowed the identification of a novel series of benzimidazole Na_V1.8 blockers. Subsequent optimization allowed the identification of compound 9, PF-06305591, as a potent, highly selective blocker with an excellent preclinical in vitro ADME and safety profile.

100 Deals associated with PF-6305591

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB12106

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Pain	Phase 1	BE	Pfizer Inc.	01 Jun 2013

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis