Last update 26 Jul 2025

SK-1404

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lazuvapagon, KRP-N118
Target
AVPR2
Action
agonists
Mechanism
AVPR2 agonists(Vasopressin V2 receptor agonists)
Therapeutic Areas
Urogenital DiseasesOther Diseases
Active Indication-
Inactive Indication
NocturiaPolyuria
Originator Organization
Sanwa Kagaku Kenkyusho Co., Ltd.Sanwa Kagaku Kenkyusho Co., Ltd.
Active Organization-
Inactive Organization
Sanwa Kagaku Kenkyusho Co., Ltd.Sanwa Kagaku Kenkyusho Co., Ltd.
License Organization
Sanwa Kagaku Kenkyusho Co., Ltd.Sanwa Kagaku Kenkyusho Co., Ltd.Beijing Xinglin Pharmaceutical Co. Ltd.
Drug Highest PhasePendingPhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC27H32N4O3
InChIKeyBKHSWGKGWGWMSM-CCLHPLFOSA-N
CAS Registry2379889-71-9

Related

3
Clinical Trials associated with SK-1404
JPRN-jRCT2080224041
/ CompletedPhase 2
A phase II randomized double blind placebo-controlled parallel-group multicenter study of KRP-N118 in patients with Nocturia due to nocturnal polyuria
NCT03116191
/ CompletedPhase 2
Trial of SK-1404 for Nocturia Due to Nocturnal Polyuria in Japanese Subjects
NCT02878096
/ CompletedPhase 1
An Open-Label, 2-Part Sequential Dose Study Designed to Assess the Absolute Bioavailability, Mass Balance Recovery, Metabolite Profile and Metabolite Identification of [14C]-SK-1404 Administered to Healthy Male Subjects
100 Clinical Results associated with SK-1404
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100 Translational Medicine associated with SK-1404
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100 Patents (Medical) associated with SK-1404
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100 Deals associated with SK-1404
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NocturiaPhase 2
Japan
Sanwa Kagaku Kenkyusho Co., Ltd.Sanwa Kagaku Kenkyusho Co., Ltd.
23 Feb 2017
PolyuriaPhase 2
Japan
Sanwa Kagaku Kenkyusho Co., Ltd.Sanwa Kagaku Kenkyusho Co., Ltd.
23 Feb 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Regulation

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