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Clinical Trials associated with Rituximab biosimilar(Hualan Genetic Engineering Co Ltd) / Not yet recruitingPhase 2IIT Efficacy and Safety of Orelabrutinib Combined With Induction Therapy Followed by Sequential Monotherapy Maintenance in MCD Subtype Diffuse Large B-cell Lymphoma: a Single-center, Single-arm, Prospective Study
This is a single-center, single-arm, prospective study aimed at evaluating the efficacy and safety of orelabrutinib combined with an induction regimen followed by monotherapy maintenance in patients with MCD subtype diffuse large B-cell lymphoma (DLBCL). The primary endpoint is the 2-year progression-free survival (PFS) rate; secondary endpoints include overall response rate (ORR), complete response rate (CRR), overall survival (OS), and treatment-related adverse events (TRAEs). The study plans to enroll 66 patients.
A Prospective, Multicenter, Open-Label, Single-Arm, Phase 2 Study to Evaluate the Efficacy and Safety of Rituximab, Pirtobrutinib, High-Dose Methotrexate, Dexamethasone, and Thiotepa (R-PMDT) in Patients With Newly Diagnosed Primary Central Nervous System Lymphoma
A total of six cycles of the R-PMDT regimen (rituximab, pirtobrutinib, high-dose methotrexate, dexamethasone, and thiotepa) will be administered to patients with newly diagnosed primary central nervous system lymphoma (PCNSL). The primary objective is to assess the overall response rate (ORR) of R-PMDT. Secondary objectives include evaluating the complete response rate, progression-free survival (PFS), overall survival (OS), and safety.
Start Date20 May 2026 |
Sponsor / Collaborator- |
比较HL03/WBP263与利妥昔单抗联合CHOP化疗药治疗初治弥漫性大B细胞淋巴瘤有效性和安全性的III期临床研究
[Translation] Phase III clinical study comparing the efficacy and safety of HL03/WBP263 and rituximab combined with CHOP chemotherapy in the treatment of newly diagnosed diffuse large B-cell lymphoma
主要目的:评价HL03/WBP263和美罗华®在初治弥漫性大B细胞淋巴瘤(DLBCL)患者中疗效的相似性。 次要目的:评价HL03/WBP263和美罗华®在初治弥漫性大B细胞淋巴瘤(DLBCL)患者中的安全性、药代动力学特征及免疫原性。
[Translation] Primary objective: To evaluate the similarity of efficacy between HL03/WBP263 and Rituximab® in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). Secondary objective: To evaluate the safety, pharmacokinetic characteristics and immunogenicity of HL03/WBP263 and Rituximab® in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
100 Clinical Results associated with Rituximab biosimilar(Hualan Genetic Engineering Co Ltd)
100 Translational Medicine associated with Rituximab biosimilar(Hualan Genetic Engineering Co Ltd)
100 Patents (Medical) associated with Rituximab biosimilar(Hualan Genetic Engineering Co Ltd)
100 Deals associated with Rituximab biosimilar(Hualan Genetic Engineering Co Ltd)