Delving into the Latest Updates on Iodohippurate Sodium I-131 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Nephroflow

Target-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Bracco Diagnostics, Inc.

Active Organization-

Inactive Organization

Bracco Diagnostics, Inc.GE Healthcare Ltd. (United Kingdom)

Drug Highest PhaseWithdrawn

First Approval Date

US (25 Jun 1970)

Regulation-

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Structure

Molecular FormulaC9H8INNaO3

InChIKeyXQBPSPHCFFEPOI-UDYUCQKZSA-N

CAS Registry881-17-4

Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor associated with long-term mortality among different patient populations. Renal dysfunction and subsequent chronic kidney disease is implicated in the development of hypertension and cardiovascular disease. The investigators overall hypothesis is that, in the pediatric population, sepsis-related AKI will have unrecognized, long-term consequences with regard to kidney function, endothelial function, blood pressure control, and overall health.

Start Date01 Oct 2019

Sponsor / Collaborator

University of Florida

[+1]

NCT02599844 / WithdrawnNot ApplicableIIT

Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis in Young Adults - IMPRESS YA

Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor associated with long-term mortality among different patient populations. Renal dysfunction and subsequent chronic kidney disease is implicated in the development of hypertension and cardiovascular disease. The investigators overall hypothesis is that, in the pediatric population, sepsis-related AKI will have unrecognized, long-term consequences with regard to kidney function, endothelial function, blood pressure control, and overall health.

Start Date01 Dec 2015

Sponsor / Collaborator

University of Florida

[+1]

100 Clinical Results associated with Iodohippurate Sodium I-131

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100 Translational Medicine associated with Iodohippurate Sodium I-131

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100 Patents (Medical) associated with Iodohippurate Sodium I-131

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3

Literatures (Medical) associated with Iodohippurate Sodium I-131

01 Mar 1981·Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Chemical and biological studies of Tc-99m N,N'-bis(mercaptoacetamido)-ethylenediamine: a potential replacement for I-131 iodohippurate.

Article

Author: Klingensmith, W C ; Kuni, C C ; Whitney, W P ; Fritzberg, A R

The tetradentate chelating agent N,N'-bis(benzoylmercaptoacetamido)ethylenediamine was synthesized for evaluation as a potential technetium-99m renal-function radiopharmaceutical. Complexes were prepared using different reducing agents and analyzed by high-performance liquid chromatography. Biological studies were performed in mice, rats, and rabbits and indicated that the new agent is cleared by the kidneys significantly faster than Tc-99m DTPA (p less than 0.01) and slightly slower than I-131 o-iodohippuric acid (p greater than 0.05). There was no evidence of significant renal retention. Renal excretion in all species studied was 70--75% of the injected dose in 30 min; biliary excretion in rats was 7% in animals with normal renal function and 18% in 90 min in the absence of renal function. We conclude that limited clinical trials are warranted.

01 Oct 1974·Acta Physiologica Scandinavica

Composite Transport Systems for Iodipamide and Iodohippurate out of the Cerebrospinal Fluid in the Rat

Article

Author: Viveka Lundberg

AbstractThe mechanism for the removal of iodohippurate and iodipamide from the CSF in rats was studied by ventriculo‐cisternal perfusion and by uptake experiments with choroid plexus in vitro. In agreement with finclings in other species excised plexus from the lateral ventricles accumulates 131I‐o‐iodohippurate and 125I‐iodipamide, and the process is at least partly saturable. Ventriculo‐cisternal perfusions were performed on pentobarbital anesthetized rats with a fluid containing 131I‐o‐iodohippurate, 125I‐iodipamide and 14C‐inulin. A considerable loss of iodohippurate and iodipamide, but not of inulin, from the CSF was observed during the perfusion. When sodium hippurate and/or non‐labelled iodipamide were added in excess to the infusion fluid the loss of labelled iodohippurate and iodipamide was reduced. In concentrations which reduced iodohippurate loss equally, hippurate and iodipamide had different effects on iodipamide loss: hippurate had less effect. This indicates that iodohippurate and iodipamide are removed from the CSF partly by saturable and presumably active transport, and that iodipamide is transported both by the same system as iodohippurate and also by a separate hippurate‐insensitive one. Choroid plexus can be one locus of this transport.

01 Aug 1962·NatureQ1 · CROSS-FIELD

Purity and Stability of Commercial Sodium Iodohippurate labelled with Iodine-131

Q1 · CROSS-FIELD

Article

Author: Gösta Magnusson

Radio-Hippuran was studied by electrophoresis at pH 5.5 and by chromatography with BuOH/HOAc/H₂O and AmOH/pyridine/H₂O.Each method showed 85-90% identified as iodohippurate and the rest as iodide.Storage in glass in daylight accelerated decompn

100 Deals associated with Iodohippurate Sodium I-131

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