Last update 05 Feb 2026

IVB-107

Overview

Basic Info

Drug Type
AAV based gene therapy
Synonyms
IVB 107, IVB107, PUMCH-E101
+ [1]
Target
RDH12
Action
modulators
Mechanism
RDH12 modulators(retinol dehydrogenase 12 modulators)
Therapeutic Areas
Cardiovascular DiseasesCongenital DisordersEndocrinology and Metabolic Disease+ [2]
Active Indication
Diabetic RetinopathyRetinitis Pigmentosa
Inactive Indication-
Originator Organization
Beijing Innovic Pharmaceutical Technology Co., Ltd.Beijing Innovic Pharmaceutical Technology Co., Ltd.
Active Organization
Peking Union Medical College HospitalPeking Union Medical College HospitalBeijing Nuowei Biomedical Technology Co., Ltd.Beijing Innovic Pharmaceutical Technology Co., Ltd.Beijing Innovic Pharmaceutical Technology Co., Ltd.
Inactive Organization-
License Organization
Peking Union Medical College HospitalPeking Union Medical College HospitalBeijing Innovic Pharmaceutical Technology Co., Ltd.Beijing Innovic Pharmaceutical Technology Co., Ltd.
Drug Highest PhaseEarly Phase 1
First Approval Date-
Regulation-
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Related

3
Clinical Trials associated with IVB-107
ChiCTR2500114927
/ Not yet recruitingNot ApplicableIIT
Extension Study of the PUMCH-E101 Clinical Trial: An open-label, single-center, single-dose study evaluating the safety, tolerability, and efficacy of intravitreal injection of PUMCH-E101 in patients with hereditary retinal diseases associated with RDH12 gene mutations in the contralateral eye.
NCT06749639
/ RecruitingEarly Phase 1IIT
An Open-Label, Single-Center, Dose-Escalation Clinical Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of Intravitreal Injection of PUMCH-E101 in Subjects with RDH12 Retinopathy
ChiCTR2400089755
/ Not yet recruitingEarly Phase 1IIT
An Open-Label, Single-Center, Dose-Escalation Clinical Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of PUMCH-E101 Administered by Intravitreal Injection in Subjects with Inherited Retinal Diseases Associated with RDH12 mutation
100 Clinical Results associated with IVB-107
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100 Translational Medicine associated with IVB-107
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100 Patents (Medical) associated with IVB-107
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100 Deals associated with IVB-107
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diabetic RetinopathyPhase 1
China
Peking Union Medical College HospitalPeking Union Medical College Hospital
20 Sep 2024
Retinitis PigmentosaPhase 1
China
Beijing Innovic Pharmaceutical Technology Co., Ltd.Beijing Innovic Pharmaceutical Technology Co., Ltd.
20 Sep 2024
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Clinical Result

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Clinical Trial

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Approval

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Regulation

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