Last update 02 Oct 2025

PF-08046876

Overview

Basic Info

Drug Type
Antibody drug conjugate (ADC)
Synonyms-
Target
ITGB6 x Top I
Action
inhibitors
Mechanism
ITGB6 inhibitors(integrin subunit beta 6 inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease+ [3]
Active Indication
Adenocarcinoma of EsophagusAdvanced Lung Non-Small Cell CarcinomaAdvanced Malignant Solid Neoplasm+ [6]
Inactive Indication-
Originator Organization
Pfizer Inc.Pfizer Inc.
Active Organization
Pfizer Inc.Pfizer Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Structure/Sequence

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Related

1
Clinical Trials associated with PF-08046876
NCT07090499
/ RecruitingPhase 1
A Phase 1 Open-label Study to Investigate PF-08046876 in Adult Participants With Advanced Solid Tumors.
100 Clinical Results associated with PF-08046876
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100 Translational Medicine associated with PF-08046876
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100 Patents (Medical) associated with PF-08046876
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100 Deals associated with PF-08046876
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenocarcinoma of EsophagusPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Advanced Lung Non-Small Cell CarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Advanced Malignant Solid NeoplasmPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Bladder CancerPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Esophageal Squamous Cell CarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Gastroesophageal junction adenocarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Pancreatic adenocarcinomaPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Squamous Cell Carcinoma of Head and NeckPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
Urothelial Carcinoma of the Urinary BladderPhase 1
United States
Pfizer Inc.Pfizer Inc.
20 Aug 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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