Two new prunasines, 6 ' ‐ O ‐ p‐trans ‐coumaroyl prunasin ( 1 ) and 6 ' ‐ O ‐ p‐cis ‐coumaroyl prunasin ( 2 ), together with six known compounds, afzelin ( 3 ), tamarixetin 3‐ O ‐rhamnoside ( 4 ), mearnsitrin ( 5 ), c is ‐linalool‐3,6‐oxide β ‐D‐glucopyranoside ( 6 ), n ‐hexyl‐ O‐β ‐D‐glucoside ( 7 ), and cucurbitacin F ( 8 ), were isolated from the leaves of Elaeocarpus bachmaensis collected in Bach Ma National Park, Vietnam. Their chemical structures were elucidated by one‐dimensional nuclear magnetic resonance (1D‐NMR), 2D‐NMR, and high‐resolution mass spectrometry spectra. Bioassays revealed that compound 6 inhibited α‐amylase significantly with a half‐maximal inhibitory concentration (IC 50 ) value of 137.3 ± 14.4 µM, whereas compounds 1 – 5 inhibited α‐glucosidase significantly with IC 50 values ranging from 82.4 ± 10.4 to 160.0 ± 19.9 µM. These findings suggest that E. bachmaensis may serve as a promising natural source for the development of antidiabetic agents. This is the first report on the chemical composition and bioactivity of the E. bachmaensis species.

01 Jan 2026·Bioscience of Microbiota Food and Health

Comparison of plasma and cecal quercetin in <i>Enterococcus</i> sp. rutin_18 mono-associated and germ-free mice fed rutin-supplemented diet

Article

Author: NAKAGAWA, Hiroyuki ; HIRAYAMA, Kazuhiro ; NAKANO, Ayumi ; TAMURA, Motoi

Rutin is a functional compound with both antioxidant and anti-cancer properties. The hydrolysis of rutin glycosides by intestinal bacteria is important for rutin absorption. We isolated Enterococcus sp. rutin_18, an intestinal bacterium that can convert rutin to quercetin, and investigated the possibility of Enterococcus sp. rutin_18-mediated rutin conversion to quercetin in vivo using mono-associated mice. We compared the plasma and cecal quercetin levels in rutin-metabolizing Enterococcus sp. rutin_18 mono-associated (Entero) and germ-free (GF) mice fed a rutin-supplemented diet. The plasma quercetin, isorhamnetin, and tamarixetin concentrations were significantly higher in the Entero mice than in the GF mice. The cecal rutin concentration was significantly lower in the Entero mice than in the GF mice (p<0.001). We found that Enterococcus sp. rutin_18 converted rutin to quercetin in the Entero mice. We infer that the Enterococcus sp. rutin_18 used in this study is an important intestinal bacterium that converts rutin to quercetin.

17 Dec 2025·NATURAL PRODUCT RESEARCH

In-silico evaluation of phytochemicals for vitiligo: ADMET, molecular docking, and MD simulation approaches

Article

Author: Arya, Vedpriya ; Sharma, Dushyant ; Katiyar, Prashant ; Balkrishna, Acharya ; Dabas, Anurag ; Singh, Netrapal

Vitiligo is a prevalent autoimmune disease affecting the quality of life and self-confidence. Total 25 phytochemicals from plants were screened by using four target proteins involved in the pathogenesis of vitiligo. The binding affinity of the ligands ranged between -10.3 and -4.5 kcal/mol. The top 10 phytochemicals i.e. rosmarinic acid, piperine, tamarixetin, desmethoxycurcumin, bisdemethoxycurcumin, isorhamnetin, quercetin, vicenin II, genkwanin, and aloe-emodin showed good inhibition with binding affinity ranged from -10.3 to 9.4 Kcal. The ADMET profiling revealed that these phytochemicals might be safe for the treatment of vitiligo. In MD simulation, rosmarinic acid, piperine, and tamarixetin with MAO-A formed stable complexes and the free binding energies of the complexes were -34.02 ± 6.94, -33.51 ± 2.65, and -27.17 ± 3.28. Furthermore, the ligands formed hydrogen bonds with targets, suggested that rosmarinic acid, piperine, and tamarixetin have potential to serve as lead compounds for developing novel therapeutics for vitiligo after in vitro and in vivo studies.

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Indication	Highest Phase	Country/Location	Organization	Date
Ischemic stroke	Preclinical	China	Northeastern University	08 Jul 2024
Staphylococcus Aureus Infections	Preclinical	China	Changchun University of Chinese Medicine	14 Jul 2022

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