The current proposal is designed as a first-in-human Phase 1 open-label, dose-escalation study to assess the safety, pharmacokinetics, and the maximum tolerated dose of DHM among healthy volunteers using a purified form of DHM from a local cGMP compliant source (Master Herbs, Inc).

Start Date15 Sep 2024

Sponsor / Collaborator

University of Southern California

JPRN-UMIN000042938

/ CompletedNot Applicable

Investigation of ampelopsin absorption by different dosage forms: An open-label, randomized, three-drug, three-period, Latin square design, crossover study - Investigation of ampelopsin absorption by different dosage forms

Start Date07 Jan 2021

Sponsor / Collaborator

FANCL Corp.

NCT03606694

/ Active, not recruitingPhase 2

Effect of Dihydromirycetin Administration on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Patients With Type 2 Diabetes Mellitus

Dihydromyricetin has demonstrated promising effects in glycemic control, insulin sensitivity and insulin secretion, that above mentioned findings show that dihydromyricetin has an excellent potential effect in the treatment of type 2 diabetes mellitus patients.

Start Date30 Oct 2019

Sponsor / Collaborator

University of Guadalajara

100 Clinical Results associated with Dihydromyricetin

100 Translational Medicine associated with Dihydromyricetin

100 Patents (Medical) associated with Dihydromyricetin

1,988

Literatures (Medical) associated with Dihydromyricetin

01 Apr 2025·Food Chemistry

A study on the qualitative analysis of lotus seedpod oligomeric procyanidins during digestion, absorption and colonic fermentation based on UPLC-Q-Exactive/MS

Article

Author: He, Boqian ; Wu, Qian ; He, Yi ; Wang, Yaxiong ; Bao, Chenxu ; Li, Liangchao

Polyphenols have potent antioxidant properties, but are easily degraded in the gastrointestinal tract, greatly limiting their application as dietary supplements. Therefore, the composition changes of lotus seedpod oligomeric procyanidins (LSOPC) in the gastrointestinal digestion, colonic fermentation and their absorption in Caco-2 cell monolayer were studied. The extracted LSOPC were identified using UPLC-Q-Exactive/MS, and a total of 47 compounds were identified. After gastrointestinal digestion, succinic acid, protocatechuic acid, p-Hydroxybenzoic acid, azelaic acid, and dihydroxyphenylacetic acid were released. Compared to gastrointestinal digestion, the total phenolic content and antioxidant capacity of LSOPC were significantly higher after colonic fermentation (P < 0.05). In addition, catechin (2.5%) crossed the Caco-2 cell monolayer and entered systemic circulation. Most of the LSOPC were not absorbed but instead entered the colon, where they were degraded to phenolic acids by gut microbiota. At the same time, unabsorbed LSOPC and their metabolites modulated the composition of gut microbiota, decreasing the Firmicutes/Bacteroidetes ratio and promoting the generation of short-chain fatty acids, especially acetic acid. Phenylacetic acid, p-Hydroxyphenylpropionic acid, p-coumaric acid, dihydroxyphenyl-ɤ-valerolactone, and 4-(3,4'-dihydroxyphenyl) valeric acid could not be detected until after colonic fermentation. It is the first time to systematically clarify compositional transformations of LSOPC during gastrointestinal digestion and colonic fermentation, which will pave the way for increasing the economic value of lotus seedpod and provide a theoretical basis for polyphenols as dietary supplements.

15 Mar 2025·Journal of the Science of Food and Agriculture

Comprehensive analysis of the metabolism of core microorganisms in polyphenolic compound formation during the acetic acid fermentation stage of millet vinegar

Article

Author: Yan, Yongheng ; Sun, Ronglong ; Fu, Maorun ; Yang, Dan ; Huang, Yanhong ; Zhang, Xingrong ; Zhang, Min

AbstractBACKGROUNDPolyphenolic compounds in millet vinegar are crucial functional substances, but the mechanisms underlying their formation and metabolism remain unclear. Acetic acid fermentation (AAF) represents the most active microbial metabolism stage and is pivotal for forming polyphenolic compounds. This study comprehensively analyzed the role of the microbiome in polyphenolic compound production and metabolism during AAF.RESULTSChanging patterns were observed in both the microbiome and polyphenolic monomer compounds during AAF of millet vinegar. Lactobacillus harbinensis (0.624–0.454%) was identified as the dominant species in the pre‐AAF stage, exhibiting a significant positive correlation with caffeic acid, kaempferic acid and kaempferolide (P < 0.05). Lactobacillus harbinensis‐mediated polyphenolic compound metabolism was further confirmed through genomic analysis and pure culture fermentation techniques. Lactobacillus harbinensis encodes enzymes such as carbohydrate hydrolases, glycosidases and cellulases, which promote the release and metabolism of polyphenolic compounds from grain hulls.CONCLUSIONThis study confirmed that L. harbinensis, as a core microorganism in millet vinegar fermentation, can significantly augment the content of total phenols and specific polyphenolic compounds. These findings provide valuable insights for optimizing millet vinegar production. © 2024 Society of Chemical Industry.

01 Mar 2025·International Journal of Biological Macromolecules

Chitosan-pullulan edible coating loaded with dihydromyricetin: Enhanced antioxidant activity and barrier properties to prolong Cantonese sausages' shelf-life

Article

Author: Yang, Mingyue ; Xu, Xiaoyan ; Tian, Xingguo

Cantonese sausages are susceptible to oxidative deterioration during storage. Compared with synthetic antioxidants, dihydromyricetin (DMY) is a natural active substance with various functions such as antioxidant and antimicrobial. In this study, edible coating solutions loaded with DMY were prepared based on chitosan (CS) and pullulan (PUL) to prolong the shelf-life of Cantonese sausages. FT-IR and XRD results showed good compatibility between DMY and CS-PUL. It was found that 8 % DMY was physically cross-linked with CS and PUL mainly through hydrogen bonding, which enhanced the barrier and mechanical properties of the films. Meanwhile, the antioxidant property, antimicrobial efficiency and thermal stability of the films were also significantly improved (p < 0.05). The results of storage experiments of Cantonese sausages showed that the 8 % DMY-CP coating solution could effectively retard the lipid oxidation of Cantonese sausages at 25 °C, and maintain the appearance and flavour of products at storage on the 28th d. This study proved DMY's potential as a natural alternative to synthetic additives in polysaccharide-based edible coatings, providing a green and sustainable solution to combat lipid oxidation in meat products.

News (Medical) associated with Dihydromyricetin

26 Jan 2024

·www.prnewswire.com

Three Journal of Pharmaceutical Analysis Studies Explore the Use of Traditional Chinese Medicine for Various Diseases

XI'AN, China, Jan. 26, 2024 /PRNewswire/ -- Despite demonstrating significant clinical efficacy against various diseases, the widespread use of Traditional Chinese Medicine (TCM) is still limited. This is mainly due to the complexity in their formulation and lack of sufficient pharmacological and safety-related data. To address this gap, a new issue of the Journal of Pharmaceutical Analysis presents three independent studies which assessed the potency of TCM-based compounds for various human diseases, along with their molecular mechanisms of action. Continue Reading Latest research unveils the potential of Traditional Chinese Medicine compounds for the treatment of human diseases The accumulation of excess fat in the liver leads to non-alcoholic fatty liver disease (NAFLD). Oridonin (ORI), a TCM derived from the Chinese herb Rabdosia rubescens, exhibits anti-inflammatory effects. An article available online on 21 August 2023 and published in Volume 13, Issue 11 of the journal in November 2023, now reveals that ORI regulates lipid homeostasis in the liver by maintaining the balance between triglyceride (TG) and phosphatidylethanolamine (PE), through modulation of adipose triglyceride lipase (ATGL) and ethanolamine phosphotransferase 1 (EPT1) expression via the liver X receptor alpha (LXRα) signaling pathway. "When the TG-PE lipid balance is disturbed, the seesaw tilts towards TG, increasing the risk of NAFLD. Restoring lipid homeostasis using compounds like oridonin can alleviate lipid accumulation and liver cytotoxicity," explains Professor Lan Tang. Tumor heterogeneity compromises the efficacy of radiotherapy for treating lung cancer. Radiosensitizers help prime tumor cells and improve their response to radiation. Now, in an article available online on 7 June 2023 and published in Volume 13, Issue 11 of the journal in November 2023, researchers found that ginsenoside Rg5 induced cell-cycle arrest and enhanced radiation-induced cell death. Ginsenoside Rg5 interacts with heat shock protein alpha (HSP90α) with high affinity and reduces the binding between HSP90 and cell division cycle 37 (CDC37), promoting HSP90-CDC37 client protein degradation. "Ginsenoside Rg5 can be potentially developed into a new drug for improving the sensitivity of lung cancer and other types of tumors to radiation therapy," the authors explain. Diabetic retinopathy (DR) is characterized by the activation of oxidative stress pathways in response to high glucose. In a study available online on 12 May 2023 and published in Volume 13, Issue 11 of the journal in November 2023, researchers synthesized a polymeric drug complex by combining a natural flavonoid antioxidant known as dihydromyricetin (DMY) with iron (Fe) ions in nano-coordinated polymer particles (NCPs). Fe-DMY NCPs can alleviate glucose-induced oxidative damage and reverse the pathological features of DR by decreasing the expression of key proteins involved in microvascular dysfunction. Fe-DMY NCPs could also inhibit the activation of Poldip2-Nox4-H2O2 signaling pathway and down-regulate important vascular function indicators such as VCAM-1, HIF-1α, and VEGF. Explaining its applications, the authors say, "We report for the first time the synthesis and validation of ultra-small Fe-DMY NCPs. Fe-DMY complexes bear the potential to alleviate the impact of DR on vision, thus improving the quality of life of affected individuals." These studies provide a scientific basis for the development of TCM-based compounds into effective targeted therapies for various diseases. Reference Titles of original papers: Oridonin restores hepatic lipid homeostasis in an LXRa-ATGL/EPT1 axis-dependent manner Ginsenoside Rg5 enhances the radiosensitivity of lung adenocarcinoma via reducing HSP90-CDC37 interaction and promoting client protein degradation Nanoscale coordination polymer Fe-DMY downregulating Poldip2-Nox4-H2O2 pathway and alleviating diabetic retinopathy Journal name: Journal of Pharmaceutical Analysis DOI: Media contact Mengjie Wang [email protected] Xi'an, China +86-(0)29-88960092 SOURCE Journal of Pharmaceutical Analysis

100 Deals associated with Dihydromyricetin

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Diabetes Mellitus, Type 2	Phase 2	Mexico	University of Guadalajara	30 Oct 2019
Alcohol-Related Disorders	Phase 1	United States	University of Southern California	15 Sep 2024
Liver Diseases, Alcoholic	Phase 1	United States	University of Southern California	15 Sep 2024
Influenza, Human	Preclinical	China	Southern Medical University	01 Jul 2020

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