Male rats were administered a single i.p. injection (90 mg/kg) of Firemaster FF-1 [67774-32-7], Firemaster BP-6 [59536-65-1], or a reconstituted mixture formulated to resemble Firemaster BP-6 to see if the pure congeners account for the toxicity of Firemaster.The reconstituted mixture was composed of 9 purified congeners, totalling nearly 97% of either Firemaster mixtureThe treatments were compared for their effects on hepatic microsomal drug-metabolizing enzymes, body weight gain, and on the weights of selected organs 1 wk after treatment.NADPH-cytochrome c reductase [9023-03-4], aminopyrine N-demethylase [9037-69-8], And epoxide hydrase [9048-63-9], typically induced by phenobarbital, were similarly induced by all mixturesThe content of cytochrome P 450 [9035-51-2] hemoproteins was nearly quadrupled by all treatments; however, the absorption maximum of the difference spectra were shifted more by Firemaster BP-6 and the reconstituted mixture than by Firemaster FF-1.In agreement with this observation, Firemaster BP-6 and the reconstituted mixture also more significantly increased the cytochrome P 450 Et isocyanide 455:430 nm difference spectral ratio, and the activities of benzo[a]pyrene hydroxylase [9037-52-9] and p-nitrophenol-UDP-glucuronyltransferase [9030-08-4], all of which are typically induced by 3-methylcholanthrene.Effects on body weight gains were similar for all treatments and although less than control they were not statistically different.Only the thymic weights of animals treated with the reconstituted mixture were significantly less than controls.Thus, the effects of Firemaster (FF-1 or BP-6) must be due to the effects of the congeners studied, and no other component in these mixtures, a brominated biphenyl or otherwise, may significantly contribute to these effects.

01 Apr 1982·Environmental Health PerspectivesQ1 · ENVIRONMENTAL SCIENCE & ECOLOGY

Toxicity of polybrominated biphenyls (PBBs) in Domestic and laboratory animals.

Q1 · ENVIRONMENTAL SCIENCE & ECOLOGY

ReviewOA

Author: Guthrie, Janet ; Vouk, Velimir B. ; Bernheim, N. Jean ; Jurgelski, William Jr. ; Luster, Michael ; Damstra, Terri ; Falk, Hans L. ; Posner, Herbert S.

The composition, environmental fate, and effects of the polybrominated biphenyls (Firemaster BP-6 or FF-1) involved in the accidental contamination of cattle feed in Michigan in 1973 are reviewed. Toxic effects referred to in this report are limited to those occurring in domestic and laboratory animals and include general toxicity, neurobehavioral toxicity, immunotoxicity, reproductive toxicity, mutagenicity and carcinogenicity. The absorption, distribution, biotransformation and elimination of these polybrominated biphenyls are discussed along with the interactions with other chemicals and drugs.

01 Oct 1978·Experimental Biology and Medicine

Polybrominated Biphenyls in Chicken Eggs vs. Hatchability

Article

Author: R. K. Ringer ; Donald Polin

A relation between polybrominated biphenyl, Firemaster FF-1 (FF-1) [67774-32-7], in the diet, and eggs, as monitored by hexabromobiphenyl (6-BB), and embryo toxicity, as measured by hatchability, were examinedThe min. dietary level of FF-1 for an effect on hatchability was estimated at 42 ppm, which produced an egg residue estimated at 65.9 ppm 6-BB.Generally, as FF-1 in the diet increased, egg residues increased and hatchability decreased.Regression equations were established for these relationships.After withdrawal of FF-1 in the diet, hatchability returned to normal when FF-1 treatments had been <625 ppm.Over a range of 30-85 ppm 6-BB in eggs there was poor correlation to an effect on hatchability.These latter data were discussed in terms that the 6-BB peak may not be a definitive approach to assess FF-1 toxicity.

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	CH	Institute of Oncology Research	08 Apr 2024

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