Delving into the Latest Updates on HPN-01 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

HPN 01

Target

SREBF1 x SREBP-2

Mechanism

SREBF1 inhibitors(Sterol regulatory element binding transcription factor 1 inhibitors), SREBP-2 inhibitors(Sterol regulatory element-binding protein 2 inhibitors)

Therapeutic Areas

Digestive System Disorders

Active Indication-

Inactive Indication

Nonalcoholic Steatohepatitis

Originator Organization

Shanghai Hepuhua Pharmaceutical Technology Co Ltd

Active Organization

Shanghai Hepuhua Pharmaceutical Technology Co Ltd

Inactive Organization

Hepanova, Inc.Startup

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

Structure

Molecular FormulaC19H16ClN3O3S

InChIKeyXJLFMRGTLRIXDT-UHFFFAOYSA-N

CAS Registry928655-63-4

主要目的：考察健康受试者单、多次口服给予HPN-01肠溶胶囊的安全性和耐受性；次要目的：评价健康受试者单、多次口服给予HPN-01肠溶胶囊的药代动力学特性；评价食物对健康受试者单次服用HPN-01肠溶胶囊后药代动力学特性的影响；

[Translation]

Main purpose: To investigate the safety and tolerability of HPN-01 enteric-coated capsules after single and multiple oral administration to healthy subjects; Secondary purpose: To evaluate the pharmacokinetic properties of HPN-01 enteric-coated capsules after single and multiple oral administration to healthy subjects; To evaluate the effect of food on the pharmacokinetic properties of HPN-01 enteric-coated capsules after single administration to healthy subjects;

Start Date23 Apr 2021

Sponsor / Collaborator

Shanghai Hepuhua Pharmaceutical Technology Co Ltd

NCT04481594 / Unknown statusPhase 1

A Randomized, Double-Blind, Placebo Controlled, Sequential Parallel Group, Single and Multiple Ascending Doses (SAD/MAD) Study Following Oral Administration in Healthy Subjects to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HPN-01

This study is a randomized, double-blind, placebo-controlled first-in-human study in which the safety, tolerability, pharmacokinetics and pharmacodynamics of orally administered HPN-01 will be evaluated in healthy subjects

Start Date08 Sep 2020

Sponsor / Collaborator

Hepanova, Inc.Startup

100 Clinical Results associated with HPN-01

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100 Translational Medicine associated with HPN-01

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100 Patents (Medical) associated with HPN-01

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100 Deals associated with HPN-01

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