KTX-201: A Multi-centre, Phase 2a, Double-blind, Placebo-controlled, Randomised Study to Examine the Safety, Tolerability, and Efficacy of KNX100 in the Treatment of Subjects with Agitation Associated with Dementia

Start Date19 Aug 2024

Sponsor / Collaborator

Kinoxis Therapeutics Pty Ltd.Startup

NCT04901078 / CompletedPhase 1

A Phase 1 Study Investigating the Safety, Tolerability and Pharmacokinetics of KNX100 in Healthy Volunteers

The primary objectives of this study are to evaluate the safety and tolerability of KNX100 administered orally as a single and multiple ascending doses in healthy volunteers.

Start Date07 Apr 2022

Sponsor / Collaborator

Kinoxis Therapeutics Pty Ltd.Startup

[+1]

100 Clinical Results associated with KNX-100

100 Translational Medicine associated with KNX-100

100 Patents (Medical) associated with KNX-100

Literatures (Medical) associated with KNX-100

15 Apr 2004·OncogeneQ1 · MEDICINE

SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

Q1 · MEDICINE

Article

Author: Akihiko Yoshimura ; Yukihiro Nagata ; Mamoru Hasegawa ; Takafumi Yoshida ; Makoto Inoue ; Yoshikazu Yonemitsu ; Tsutomu Douchi ; Hisanobu Ogata ; Masaki Kamio

Human papilloma viruses (HPVs) are small double-stranded DNA viruses that infect mucosal and cutaneous epithelium and induce cervical cancer. It has been shown that interferon (IFN)gamma suppresses proliferation of HPV-infected cells by suppressing expression of HPV E7. Here, we found that IFNgamma induces not only suppression of E7 transcription but also proteasome-dependent degradation. Suppressor of cytokine signaling-1 (SOCS1)/JAB, a suppressor of cytokine signaling, is known to be induced by IFNgamma, and functions as an antioncogene against various hematopoietic oncogenic proteins. SOCS1 contains the SOCS-box, which is shown to recruit ubiquitin transferase to the molecules that interact with SOCS1. We found that SOCS1 interacted with HPV E7 protein and induced ubiquitination and degradation of E7 in a SOCS-box-dependent manner. SOCS1 overexpression also increased Rb protein levels and suppressed proliferation of cervical cancer cell lines infected with HPV. Moreover, E7 protein levels were higher and Rb protein levels were lower in SOCS1-deficient fibroblasts infected with retrovirus vector carrying E7 gene than in wild-type fibroblasts. E7 induced anchorage-independent growth in SOCS1-deficient fibroblasts, but not in wild-type cells. These data suggested that SOCS1 plays an important role in regulating the levels of E7 protein and their transforming potential, and could be a new therapeutic tool for HPV-mediated tumors.

100 Deals associated with KNX-100

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Opium Dependence	Phase 1	AU	Kinoxis Therapeutics Pty Ltd.Startup	22 Jul 2022
Opioid-Related Disorders	Phase 1	AU	Kinoxis Therapeutics Pty Ltd.Startup	07 Apr 2022
Agitation	Preclinical	AU	Kinoxis Therapeutics Pty Ltd.Startup	22 Jul 2022
Substance Abuse	Preclinical	AU	Kinoxis Therapeutics Pty Ltd.Startup	22 Jul 2022

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