Last update 20 Mar 2025

CC-97489

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
FAAH/MGLL dual inhibitor
Target
FAAH x MAGL
Action
inhibitors
Mechanism
FAAH inhibitors(Anandamide amidohydrolase inhibitors), MAGL inhibitors(Monoglyceride lipase inhibitors)
Therapeutic Areas
Nervous System Diseases
Active Indication-
Inactive Indication
Nervous System Diseases
Originator Organization
Bristol-Myers Squibb Pharmaceuticals Ltd.
Active Organization
Celgene Corp.Celgene Corp.
Inactive Organization
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with CC-97489
NCT05065541
/ CompletedPhase 1
A Phase 1, Open-label, Multi-part Positron Emission Tomography (PET) Imaging Study to Evaluate the Biodistribution and Radiation Dosimetry of the Monoacylglycerol Lipase (MGLL) PET Ligand [18F]T-401 and to Evaluate Fatty Acid Amide Hydrolase (FAAH) and MGLL Enzyme Availability in the Central Nervous System Using [11C]MK-3168 and [18F]T-401 PET Ligands Before and After Oral Administration of Single and Multiple Doses of CC-97489 in Healthy Adult Subjects
NCT05099822
/ TerminatedPhase 1
A Phase 1, Randomized, Double-blind, Placebo-controlled, Single-center, First-in-human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple Ascending Doses of CC-97489 in Healthy Adult Subjects
100 Clinical Results associated with CC-97489
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100 Translational Medicine associated with CC-97489
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100 Patents (Medical) associated with CC-97489
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100 Deals associated with CC-97489
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nervous System DiseasesPhase 3
Belgium
Bristol Myers Squibb Co.Bristol Myers Squibb Co.
12 Jul 2020
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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