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Last update 08 May 2025

Mannitol Nicotinate

Last update 08 May 2025

Overview

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Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

烟酸甘露醇

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Drug Highest PhaseApproved

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Structure/Sequence

Molecular FormulaC42H32N6O12

InChIKeyIMRLNFKFNFLWQF-MGXDLYCJSA-N

CAS Registry15596-27-7

100 Clinical Results associated with Mannitol Nicotinate

100 Translational Medicine associated with Mannitol Nicotinate

100 Patents (Medical) associated with Mannitol Nicotinate

Literatures (Medical) associated with Mannitol Nicotinate

Bollettino Chimico Farmaceutico

Chemical hydrolysis of inositol, mannitol, and sorbitol hexanicotinates in vitro

Author: Linari, G.

The in vitro hydrolysis of inositol, mannitol, and sorbitol hexanicotinates (I, II, and III, resp.) was investigated at the various pH values found in physiol. fluids.Hydrolysis at pH 0.90, 1.10, 2, 7, and 8.8 at 37° was studied after 0.5, 1, 2, 3, 4, 5, and 6 hr.I, II, and III were poorly hydrolyzed; the extent of hydrolysis was determined by complexometric titration of the nicotinic acid (IV) liberated (as ca salt).The percentage of IV liberated by hydrolysis at 37° of I, II, and III, resp., after 6 hr (data for other time periods are also tabulated) was as follows: pH 0.90: 8.3, 13.2, 16; pH 1.10: 4.9, 6.5, 6.2; pH 2: 1.8, 2.7, 0.9; pH 7: 1.1, 2, 1.6; pH 8.8: 3.7, 4.3, 5.1.In general, II was the most hydrolyzed.

Therapie

Nicotinic acid and various derivatives as hypolipemia-producing compounds

Author: Leprince, C. Mrs. ; Rohrbach, P.

Intravenous administration of 300 mg. Triton/kg. to rats increased only the free cholesterol fraction in the blood within 18 hrs. of administration, without altering the liver lipids; free cholesterol increased from 8 to 105 mg./100 ml.Simultaneous administration of nicotinic acid (I) (0.50 g./kg. given orally) antagonized the effects of Triton on cholesteremia; free cholesterol levels reached 64 mg./100 ml. after the combined treatment.However, I itself increased liver fatty acids from 16.5 to 22.66 g./100 g. fresh weight; this increase was not reflected in a decrease in hepatic chromagogue function.None of 14 I derivatives were more active than the parent compound as a hypocholesteremic or as a clarifying factor.N-Oxynicotinic acid, 4-acetylaminophenyl nicotinate, nicotinoylaminophenol, and nicotinamide (0.565, 1.042, 0.87, and 0.5 g./kg., resp.) were as effective as 0.5 g. I/kg. against serum cholesterol in Triton-treated rats, while 2-chloronicotinic acid, 2-iodonicotinic acid, and quinolinic acid (0.644, 1.012, and 0.783 g./kg., resp.) were inactive.The 4 compounds active against cholesterolemia plus 2-chloronicotinic acid were effective in reducing serum turbidity, while 2-methyl-5-phenylnicotinic acid increased this.4-Acetyl-aminophenol nicotinate, nicotinoylglycolic acid, mannitol hexanicotinate, sorbitol hexanicotinate, nicotinoylaminophenol, nicotinoylphenylisopropylamine, nicotinamide, and N-oxynicotinic acid (doses equivalent to 100 mg. I/kg.) showed a vasodilatory effect on the guinea pig ear which was 94, 50, 44, 40, 40, 18, 10, and 3%, resp., that of I (100 mg./kg.).A dissociation is therefore shown between hypocholesteremic, clarifying, and vasodilatory properties.

Fenxi Huaxue

Identification of mannitol niacinate by nuclear magnetic resonance

Author: Zhao, Huansui ; Hao, Shuxuan

The structure of mannitol niacinate was identified by ¹H and ¹³C-NMR spectra using distortionless enhancement by polarization transfer (DEPT) technique and determination technique of quaternary carbon.Every spectral line in spectrogram were designated.

100 Deals associated with Mannitol Nicotinate

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Mannitol Nicotinate

Overview

Basic Info

Structure/Sequence

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R&D Status

Clinical Result

Translational Medicine

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Core Patent

Clinical Trial

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Regulation