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Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Mechanism-

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Active Indication-

Inactive Indication-

Originator Organization

Wyeth AB

Active Organization-

Inactive Organization-

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First Approval Date-

Regulation-

The fermentation, isolation, and structural elucidation of the title polyether antibiotic (I) of Streptomyces salvialis are reported.Following Et acetate extraction, gel filtration and TLC, the compound was analyzed by thermospray mass spectrometry, fast-atom bombardment mass spectrometry, and ¹³C and ¹H NMR spectrometry and determined to be I.The monosaccharide structure was verified by gas chromatog./mass spectrometry.

01 Jan 1994·The Journal of AntibioticsQ4 · MEDICINE

Martinomycin, a new polyether antibiotic produced by Streptomyces salvialis. I. Taxonomy, fermentation and biological activity.

Q4 · MEDICINE

Article

Author: Joseph J. Goodman ; Cedric J. Pearce ; Michael Greenstein ; Valerie S. Bernan ; Guy T. Carter ; Deborah A. Monteregro ; William M. Maiese ; Mahender R. Alluri ; Darren R. Abbant

Actinomycete culture LL-D37187 has been found to produce the new polyether antibiotic martinomycin. Taxonomic studies, including morphological, physiological, and cell wall chemistry analyses, revealed that culture LL-D37187 is a novel streptomycete species, and the proposed name is Streptomyces salvialis. Martinomycin exhibits activity against the Southern Army Worm (Spodoptera eridania) and Gram-positive bacteria.

100 Deals associated with Martinomycin

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