Delving into the Latest Updates on Sulfadiazine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

2-sulfanilamidopyrimidine, 2-sulfanilylaminopyrimidine, 4-amino-N-2-pyrimidinylbenzenesulfonamide

+ [18]

Target

bacterial DHPS

Mechanism

bacterial DHPS inhibitors(Bacterial dihydropteroate synthase inhibitors)

Therapeutic Areas

Infectious Diseases

Active Indication

Bacterial Infections

Inactive Indication-

Originator Organization

Lederle Laboratories

Active Organization

Youhua Pharmaceutical (Leshan) Co Ltd

Vita Health Products, Inc.

Inactive Organization

Eli Lilly & Co.

AbbVie, Inc.

Lederle Laboratories

Drug Highest PhaseApproved

First Approval Date

US (11 Aug 1941),

Bacterial Infections

RegulationOrphan Drug (JP)

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Structure

Molecular FormulaC10H10N4O2S

InChIKeySEEPANYCNGTZFQ-UHFFFAOYSA-N

CAS Registry68-35-9

Obtaining the sulfonamides (SAs) concentrations in the water body and sediment bulk was a prerequisite to reveal their transport and partitioning behavior in sediment-water environments and accurately assess their ecological risk. In the present study, the influences of multifactor interactions on the performance of o-DGTs with XAD-18 binding gels were analyzed by central combination experiments and response surfaces analysis, in which the target compounds were 9 SAs. The results indicated that dissolved organic matter (DOM), pH, and suspended particulate matter (SS) had significant effects on the o-DGT sampling, whereas this o-DGT was independent of the ionic strength (IS). Concentning the composite influence of the four factors, the interaction between DOM and SS posed the most significant effect on all 9 SAs compounds. Subsequently, an o-DGT and DIFS model was applied to explore the SAs migration between the water-sediments interface. The difference between desorption rate (k_b) and adsorption rates (k_f) values suggested that the kinetics of SAs was dominated by adsorption. Moreover, the short-term sediment-water partitioning of SAs was clarified on the basis of distribution coefficient (K_dl) for the labile SAs, among which the sulfadiazine (SDZ) had the largest labile pool. The ability of sediments to release SAs to the liquid phase as a sink was determined by response time (T_c). Among the 9 SAs, the long-term release of soseulfamethoxypyridazine (SMP) from the solid phase of sediments would have a potential risk to the aquatic environment, to which more attention should be paid in the future.

01 Jan 2025·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Utilizing sulfa drugs’ pH-dependent spectral modifications for designing molecular logic gates

Article

Author: Kumar, H M Suresh ; Prachalith, N C ; Thipperudrappa, J ; Thipperudrappa, J. ; Vibha, K. ; Ravikantha, M.N. ; Prachalith, N.C. ; Vibha, K ; Reddy, R Annoji ; Reddy, R. Annoji ; Kumar, H.M. Suresh ; Ravikantha, M N

In this study, the absorption and fluorescence characteristics of sulfa drugs, specifically Sulfadiazine (SDZ), Sulfamerazine (SMZ), and Sulfamethazine (STZ), were examined across a pH range of 1-14. The absorption and fluorescence spectra of these sulfa drugs showed significant changes depending on the pH value. Analysis of their pH-dependent absorption and fluorescence properties indicated that these sulfa drugs could used to design molecular logic gates. The absorption and fluorescence behaviors at various wavelength maxima were utilized to design IMPLICATION and Improved-INHIBIT (I-INHIBIT) molecular logic gates.

01 Jan 2025·Talanta

Highly efficient and broad-spectrum antibacterial carbon dots combat antibiotic resistance

Article

Author: Li, Xinlu ; Wu, Jie ; Wang, Panyong ; Du, Yuwei ; Yan, Haiyang ; Dong, Wenfei ; You, Qiannan ; Li, Li ; Miao, Huimin

Bacterial infections have become a major global public health issue, particularly with the emergence of multidrug-resistant strains. Therefore, developing non-antibiotic antimicrobial agents is crucial for treating drug-resistant bacterial infections. Building on previous research into natural products as novel antibacterial agents, this study synthesized curcumin-derived carbon dots using curcumin and ethylenediamine as raw materials through a hydrothermal method. The resulting carbon dots not only improved the water solubility and stability of curcumin but also exhibited highly efficient broad-spectrum antibacterial activity. Detailed investigations into the antibacterial performance and mechanisms of the carbon dots were conducted through experiments such as minimum inhibitory concentration (MIC) determination, live/dead bacterial staining, morphological studies, nucleic acid concentration detection, and reactive oxygen species (ROS) detection. The results indicated that the carbon dots significantly damaged the structural integrity of bacteria and generated large amounts of ROS. They exhibited remarkable antibacterial effects against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and effectively inhibited drug-resistant MRSA. Their antibacterial efficacy was notably superior to that of broad-spectrum antibiotics such as chloramphenicol and Sulfadiazine. This study highlights the potential application of curcumin-derived carbon dots in combating bacterial infections and provides valuable insights for developing novel antibacterial agents derived from natural products.

100 Deals associated with Sulfadiazine

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External Link

KEGG	Wiki	ATC	Drug Bank
D00587	Sulfadiazine	J01EC02	DB00359

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Bacterial Infections	CA	Vita Health Products, Inc.	31 Dec 1957

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2020	Not Applicable	Nephrolithiasis \| Acute Kidney Injury	-	Sulfadiazine	fhnezuvyvq(yjzalstmoh) = Our patient developed severe but reversible post-obstructive AKI secondary to high-dose sulfadiazine-induced nephrolithiasis wizlwdszpx (bjmfgfgzhc ) View more	Negative	19 Oct 2020
NCT01553708 (CTgov)	Phase 2/3	Burns	34	silver sulfadiazine cream+Epidermal growth factor (Epidermal Growth Factor With Silver Sulfadiazine Cream)	tyjeehcqbk(gubwjgynxe) = kvzpdlguov amlihxnpyy (evdlhxvten, tgkkhwzrpq - txceolghdf) View more	-	09 Aug 2012
NCT01553708 (CTgov)	Phase 2/3	Burns	34	Silver zinc sulfadiazine cream (Silver Zinc Sulfadiazine Cream)	tyjeehcqbk(gubwjgynxe) = gbkpdnatkq amlihxnpyy (evdlhxvten, whwlkigzqv - rsjnkevqmr) View more	-	09 Aug 2012