Delving into the Latest Updates on Oxiglutatione with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

GSSG, Glutathione disulphide, Oxidized glutathione

+ [6]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System DisordersOther Diseases

Active Indication

HypoxiaLiver DiseasesPoisoning+ [1]

Inactive Indication-

Originator Organization

Takeda Pharmaceutical Co., Ltd.

Active Organization

Chongqing Yao Pharmaceutical Co., Ltd.Alcon Laboratories, Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (04 Oct 1991),

Ophthalmologic surgical procedures

Regulation-

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Structure/Sequence

Molecular FormulaC20H32N6O12S2

InChIKeyYPZRWBKMTBYPTK-BJDJZHNGSA-N

CAS Registry27025-41-8

Abstract: Atriplex halimus L. is a promising xero-halophyte species for phytoremediation purposes but displays high levels of genetic variability.As an attempt to select uniform material suitable for phytomanagement, five clones were established by cuttings from three non-polluted sites (Tunis, Nabeul and Sfax), one moderately Pb-polluted site (Sousse) and a highly polymetallic polluted mining site (Gafsa).Cuttings were cultivated during 90 days under controlled conditions on soil issued from the most polluted area.The clone from Gafsa accumulated higher concentrations of metals in roots (Cr) and leaves (Cd, Sr, Zn and Cu) than other clones.Gafsa showed the highest absorption efficiency, translocation factor, bioconcentration factor and bioaccumulation coefficient compared to other clones but displayed the lowest relative growth rate (RGR) value while the highest RGR was found in the clone from Sousse.Heavy metal tolerance in Gafsa was not related to a more efficient management of oxidative stress or higher concentration of phytochelatins.Total amount of Sr and Zn removed from the substrate was the highest for Sousse while removal of Cd, Cu, Cr and Ni was the highest for Gafsa.It is concluded that cuttings allow to obtain uniform material for phytoremediation by Atriplex halimus and that combining different clones with complementary properties is an attractive option for phytomanagement of polymetallic polluted soils by this species.

01 Jun 2025·Journal of Photochemistry and Photobiology A: Chemistry

Silver ions and bacteria as promoters of UV-A photocatalysis

Author: Tenkumo, Taichi ; Sasaki, Keiichi ; Ogawa, Toru ; Mokudai, Takayuki ; Yoda, Nobuhiro ; Iwabuchi, Taito

This study aimed to identify the ions used in disinfection treatments involving UV-A irradiation and to clarify the mechanism of free radical generation in three combinations of silver ions, Staphylococcus aureus, and UV-A irradiation, for applications in dental implants.Free radicals were analyzed 1 or 4 min after combining various ions (Na, Mg, Al, Ca, Fe, Cu, Zn, Ag, Pt, or Au) with S. aureus, followed by UV-A irradiationThe mechanism of free radical generation from the UV-A irradiation of a mixture of Ag and S. aureus was examined using ESR (ESR), NMR (NMR), X-ray diffraction, and GSH/GSSG ELISA assays.Free radicals were generated from combinations of Na, Mg, Al, Ca, Zn, and Ag ions under UV-A irradiation in bacterial suspensions, with Ag producing the highest yield among all ions.Addnl., the mixture of Fe ions and bacterial suspension generated DMPO-SG.The combination of Ag ions and UV-A irradiation in bacterial suspensions resulted in the production of hydroxyl radicals.Free radicals were also generated from all cellular fractions upon UV-A irradiation in the presence of silver, with a higher yield observed in lipopolysaccharide and peptidoglycan.The combination of silver ions and UV-A irradiation oxidized GSH to GSSG, producing thiol radicals.Silver ions in bacteria act as promoters of UV-A photocatalysis.

01 May 2025·Journal of Colloid and Interface Science

Hypoxia-Targeted-Therapy: Mussel-inspired hollow polydopamine nanocarrier containing MoS2 nanozyme and tirapazamine with anti-angiogenesis property for synergistic tumor therapy

Article

Author: Huang, Chih-Ching ; Wang, Chen-Yow ; Chang, Huan-Tsung ; Hsu, Shih-Hao ; Ciou, Sin-Yi ; Chang, Jia-Yaw ; Lee, Yu-Cheng ; Chen, Yi-Chia ; Demissie, Girum Getachew

Photothermal therapy (PTT) using thermal and tumor microenvironment-responsive reagents is promising for cancer treatment. This study demonstrates an effective PTT nanodrug consisting of hollow-structured, thermally sensitive polydopamine nanobowls (HPDA NB), molybdenum sulfide (MoS₂) nanozyme, and tirapazamine (TPZ; a hypoxia-responsive drug), with a structure of HPDA@TPZ/MoS NBs_, which is hereafter denoted as HPTZMoS NBs. With the Fenton-like activity, the HPTZMoS NBs in the presence of H₂O₂ catalyze the formation of hydroxyl radicals, providing chemodynamic therapy (CDT) effect and deactivating glutathione. Under acidic conditions, HPTZMoS NBs facilitate the release of sulfide ions (S^2-) and TPZ, providing a combination of chemotherapy (CT) and hydrogen sulfide (H₂S) gas therapy (GT). Under an 808-nm NIR laser irradiation, the HPTZMoS NBs efficiently convert photo energy to thermal energy, providing PTT and improved CDT, CT, and GT effects. Upon treatment with an NIR laser and H₂O₂, a synergistic effect leads to substantial tumor cell eradication. Additionally, HPTZMoS NBs disrupt vascular endothelial growth factor (VEGF-A₁₆₅)-induced cell migration in human umbilical vein endothelial cells through its strong interaction with VEGF-A₁₆₅. In vivo studies in 4T1-tumor-bearing mice confirm that HPTZMoS NBs induces significant tumor destruction through a combination of PTT, hyperthermia-induced CDT, GT, and CT pathways. This study presents a multifaceted, highly selective nanotherapy platform with potent anti-angiogenesis properties, holding significant promise for future clinical applications.

100 Deals associated with Oxiglutatione

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External Link

KEGG	Wiki	ATC	Drug Bank
D00031	Oxiglutatione	V03AB	DB03310

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hypoxia	China	Chongqing Yao Pharmaceutical Co., Ltd.	01 Jan 1999
Liver Diseases	China	Chongqing Yao Pharmaceutical Co., Ltd.	01 Jan 1999
Poisoning	China	Chongqing Yao Pharmaceutical Co., Ltd.	01 Jan 1999
Ophthalmologic surgical procedures	Japan	Alcon Laboratories, Inc.	04 Oct 1991

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ARVO2023	Not Applicable	-	-	Glutathione oxidized	yiqrpmhwlr(eulhlusuxc) = szsnxpvjmb cebkwfmndk (fomqkpuchx )	-	01 Jun 2023
				Raddeanin A	yiqrpmhwlr(eulhlusuxc) = aolmbcdozy cebkwfmndk (fomqkpuchx )
ARVO2006	Not Applicable	-	-	Ascorbic Acid (BSS Plus)	cphdiqafnz(aibmumteot) = sevbvfppdb zxjvtsfdhx (ozezwesqfj )	-	01 May 2006
				BSS Plus and ascorbic acid solution	cphdiqafnz(aibmumteot) = xcborxnrzb zxjvtsfdhx (ozezwesqfj )