H1 receptor inverse agonists(Histamine H1 receptor inverse agonists), Histamine receptor antagonists, α-adrenergic receptor agonists(Alpha adrenergic receptor agonists)

Therapeutic Areas

Immune System DiseasesInfectious DiseasesOtorhinolaryngologic Diseases+ [1]

Active Indication

Nasal ObstructionRhinitis, Allergic

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization

Parke-Davis & Co. Ltd.

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC10H16ClNO

InChIKeyBALXUFOVQVENIU-KXNXZCPBSA-N

CAS Registry345-78-8

View All Structures (2)

Clinical Trials associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

IRCT20170429033680N9

/ RecruitingPhase 1IIT

The effect of diphenhydramin hydrochloride gargling in the sore throat of patients undergoing cataract surgery after insertion of laryngeal mask airway

Start Date26 Feb 2014

Sponsor / Collaborator

Mashhad University of Medical Sciences

100 Clinical Results associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

100 Translational Medicine associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

100 Patents (Medical) associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

Literatures (Medical) associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

01 Jan 2016·Vestnik oftal'mologii

. Oсumethyl in the treatment of allergic diseases of eyelids and conjunctiva

Article

Author: Marchenko, N R

Treatment of allergic diseases of eyelids and conjunctiva (conjunctivites and blepharoconjunctivites) often presents difficulties due to peculiarities of their pathogenesis - allergic and vascular reactions, disorder of lacrimal production, meibomian gland dysfunction, and possible bacterial contamination. It has been suggested to use Ocumethyl, which contains zinc sulfate (binding, drying, anti-inflammatory, and antiseptic effect), diphenhydamine hydrochloride (an Н1-antihistamine that decreases capillary permeability and helps resolve conjunctival and eyelid edema), naphazoline hydrochloride (a sympathomimetic notable for its strong, rapid, and long-lasting vasoconstrictive effect), and methylene blue (antiseptic effect, disintoxication, and antioxidant activity). A total of 80 patients with chronic allergic conjunctivitis, blepharoconjuntivitis, or giant papillary conjunctivitis associated with contact lens wearing were treated with Ocumethyl instillations (3 times daily for 15-30 days). A clinically significant effect was obtained in 77-91% of patients depending on the disease entity.

01 Jul 2001·Il Farmaco

Microporous material from kanemite for drug inclusion and release

Article

Author: Ione Chiappini ; Fabio Marmottini ; Valeria Ambrogi ; Giuliano Grandolini ; Giuseppe Fardella ; Luana Perioli

A microporous material obtained from kanemite, a layered polysilicate, was studied in order to investigate its feasibility of including drugs and then releasing them. Diphenydramine hydrochloride was chosen as a model drug. The preparation of the microporous material and its loading with the drug are described. As kanemite is able to intercalate anions between its layers, the intercalation compound of diphenydramine and kanemite was also prepared. Both the drug-loaded microporous material and the intercalation compound were submitted to dissolution tests at pH 7.5. The drug release profiles from these two different materials and from a physical mixture were compared.

01 May 1976·Journal of Pharmaceutical SciencesQ3 · MEDICINE

Spectrophotometric Determination of Diphenhydramine Hydrochloride using Dipicrylamine

Q3 · MEDICINE

Article

Author: Fadhil A. Shamsa ; Rostam H. Maghssoudi

A spectrophotometric procedure for the determination of diphenhydramine hydrochloride based on the reaction with dipicrylamine was developed. A yellow complex forms and is easily extractable by chloroform at pH 5. The mole ratio of diphenydramine hydrochloride to dipicrylamine in the complex is 1:3. The absorbance of the complex obeys Beer's law over the concentration range of 3-10 mug of diphenhydramine hydrochloride per ml of chloroform. This procedure can be carried out in the presence of other compounds without interference.

100 Deals associated with Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Nasal Obstruction	CN	-	-
Rhinitis, Allergic	CN	-	-

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Diphenhydramine Hydrochloride/Pseudoephedrine Hydrochloride

Overview

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Structure/Sequence

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Translational Medicine

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Clinical Trial

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