Thiol-yne click postsynthesis of imidazole-functionalized cyclodextrin microporous organic network: A remarkable adsorbent for sulfonamide antibiotics

Author: Yang, Cheng-Xiong ; Wang, Ting ; Yue, Yun-Da ; Cui, Yuan-Yuan

Sulfonamides (SAs) are widely used broad-spectrum antibiotics for treating infections.However, their inevitable residues pose serious threats to human health and agroecosystems.Hence, reasonable design and synthesis efficient adsorbents to remove residual SAs from the environment are crucial and highly desired.In this study, a novel imidazole-functionalized cyclodextrin-based microporous organic network (α-CD-MON-BZ) was designed and synthesized through the specific thiol-yne click post-modification for the efficient removal of SAs.The prepared α-CD-MON-BZ exhibited ultrafast adsorption kinetics (<3 min) and an exceptionally high saturation adsorption capacity (571.4 mg/g) for sulfamethoxypyridazine (SMP).This capacity was much higher than those of other reported adsorbents.Fourier transform IR spectroscopy, XPS, and d. functional theory calculations revealed that the adsorption process involves hydrophobic, π-π, hydrogen bonding, host-guest, and electrostatic interactions.Furthermore, α-CD-MON-BZ exhibited favorable reusability and selectivity.This study introduces a new method to construct novel functionalized CD-MONs for highly efficient SAs removal and promotes the design and applications of such materials in contaminant removal.

01 May 2025·Journal of Hazardous Materials

Comprehensive evaluation of antibiotic pollution in a typical tributary of the Yellow River, China: Source-specific partitioning and fate analysis

Article

Author: Wang, Linfang ; Liu, Yue ; Liu, Ruimin ; Liu, Lu

The partitioning and migrating of antibiotic residues pose a considerable pollution to the river environment. However, a source-specific approach for quantifying the fate of antibiotics is lacking. To further elucidate the migration behavior of antibiotics from different pollution sources in aquatic environments, we introduced a source-specific partition coefficient (S-Kp) based on Positive Matrix Factorization (PMF) model to improve the multimedia model. This study identified six sources of antibiotic pollution in the water and sediment of the Fenhe River. Farmland drainage contributed 2.6 times more antibiotics to sediment than to surface water, whereas livestock sources contributed 0.3 times less to sediment than to water. High S-Kp values were primarily obtained from livestock, aquaculture, and farmland drainage pollution sources, with an average S-Kp value exceeding 200 L/kg. Sulfaquinoxaline (SQX) in sulfonamides (SAs) from livestock sources exhibited the highest S-Kp value of 34,740.04 L/kg. The predicted environmental concentrations indicated that almost 99 % of the antibiotics from the six sources remained in the water phase, with the highest contribution (99.9 %) of azithromycin (AZM) from livestock, pharmaceutical wastewater, and domestic sewage. This study provides novel insights into the migration of antibiotics from source-specific partitions in multimedia environments of watersheds.

01 May 2025·Journal of Colloid and Interface Science

Electrical activation of periodate by nano-zero-valent cobalt/nitrogen-doped carbon for sulfisoxazole degradation: Insights into rapid electron transfer mechanisms

Article

Author: Li, Xiaoping ; Chen, Xiaobao ; Chen, Rongzhi ; Chen, Yang ; Huang, Zonghan ; Liu, Yu ; Liu, Meng ; Yang, Shengjiong ; Ding, Dahu ; Wen, Lanxuan

Periodate (PI) activation via three-dimensional electrochemical (E) is a promising approach for degrading sulfisoxazole (SIZ), while the scarcity of active sites significantly limits the efficient electron-transfer rate. Herein, we synthesized multiple strongly active zero-valent cobalt (Co⁰) nanoparticles encapsulated in nitrogen-doped carbon (NC) shells through Co-potassium chloride (KCl) doping pyrolysis of Zeolitic Imidazolate Framework-8 (ZIF-8) to induce the rapid electron transfer pathways (ETP). Specifically, molten KCl doping provides confined structures for Co⁰ with a diameter of 12.57 nm embedded in the NC shell, thereby expanding the active space of Co⁰/NC. The generated Co⁰/NC exhibited an enormous electrochemically active surface area (ECSA, 736.92 cm²/mg), low charge transfer resistance (R_ct, 38.50 Ω), and strong adsorption energy (-6.003 eV), which together promote robust electron transfer kinetics. Capitalizing on these properties, the E-Co⁰/NC-PI system achieved 100% SIZ removal at a degradation rate of 1.587 min^-1 under near-neutral (pH 5.00-9.00) conditions, with ultra-low energy consumption (0.011 kWh m^-3, $0.125/L). This study highlights a Co⁰/NC-induced rapid ETP for SIZ removal, offering insights into enhanced electrical activation of PI for wastewater treatment.

100 Deals associated with Sulfisoxazole

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KEGG	Wiki	ATC	Drug Bank
D00450	Sulfisoxazole	S01AB02 J01EB05	DB00263

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