Immobilization of novel inorganic nano-complexes onto MWCNT nanomaterials as a novel adsorbent and anti-inflammatory therapy in an induced model of rheumatoid arthritis

Q3 · MATERIALS SCIENCE

Article

Author: Heba B Ghanem ; Rania H Taha ; Rehab G El-Sharkawy

Novel supported inorganic metal nano-complexes of Ag(I) and Co(II) derived from 4-amino-N-(4-methylpyrimidin-2-yl) benzene sulfonamide (SulMer) were synthesized using olive leaf extract as a reducing agent with grinding and microwave methods. The prepared samples were denoted as Comp1-6. The surface morphologies of the synthesized nanomaterials were analyzed using C, H, N, S analysis, Fourier-transform infrared spectroscopy, UV- visible spectroscopy, proton and carbon nuclear magnetic resonance, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and x-ray powder diffraction (XRD) analysis. The data revealed that all the synthesized complexes exhibited a 1:1 metal-to-ligand ratio with a coordination number of 4 or 6. The mean particle size of the nanomaterial samples was 25-35 nm. The XRD patterns indicated a crystalline nature for the complexes. The supported inorganic metal nano-complexes displayed good activity in the adsorptive removal of Direct Red 81 (DR-81) from aqueous solutions. In addition, the effect of the supported metal nano-complexes on the immune system was studied as well as how these anti-inflammatory compounds could be used to treat many autoimmune diseases, most notably rheumatoid arthritis. An experimental model for arthritis can be induced using complete Freund's adjuvant. It was shown that the supported complex offers several advantages such stability, eco-friendliness, simple experimental conditions, short reaction times, and easy work- up.

29 Feb 2012·Rapid Communications in Mass SpectrometryQ3 · CHEMISTRY

Identification of isobaric amino‐sulfonamides without prior separation

Q3 · CHEMISTRY

Article

Author: Wolff, Jean‐Claude ; Barry, Samantha J.

RATIONALEDirect analysis mass spectrometry (DAMS) techniques offer increased speed of analysis without the need for sample preparation or prior separation. A feature of these techniques is that all ionisable species will typically be analysed at the same time which makes the ability to distinguish between isobaric compounds increasingly important.METHODSInvestigations have been carried out to distinguish isomeric compounds by mass spectrometry only, without the use of any separation technique, in order to further understand the capabilities of DAMS techniques. The work focused on commercially available isomeric amino‐sulfonamides, i.e. sulfalene, sulfameter, sulfamethoxypyridazine, sulfamonomethoxine, sulfadoxine, sulfadimethoxine, sulfisomidine, sulfamethazine, sulfamerazine, sulfaperine, sulfadiazine and sulfapyrazine.RESULTSAll the isomeric compounds investigated could be distinguished from each other based on their tandem mass (MS/MS) spectrum or failing that, based on their MS3 spectrum. Common fragmentation patterns/pathways were observed for groups of the sulfonamides and a rationale for the fragmentations observed is proposed. For the sulfonamides which contain a methoxy group on the pyrimidinyl, pyridazynil, or pyrazinyl ring, the fragmentation‐directing feature is the positioning of the methoxy group in the ortho position of the ring with respect to the sulfonamide bond. The presence of an ortho substituent precludes the formation of the product ion resulting from the loss of aniline.CONCLUSIONSThis work has demonstrated the usefulness of MSn fragmentation data in identifying and distinguishing isobaric structural isomers without the need for separation by high‐performance liquid chromatography (HPLC), allowing the identification of compounds by DAMS techniques. This work has also highlighted patterns in the product ion data which has led to a postulation of how the protonation preference of a molecule can affect the product ions observed and how the presence of ortho substituents can affect this initial protonation preference. Copyright © 2012 John Wiley & Sons, Ltd.

01 Jan 1980·Archiv fur experimentelle Veterinarmedizin

[Pharmacokinetic studies of sulfamerazine-Na, sulfaperine-Na and sulfadimidine-Na in the hen].

Article

Author: Losch, K

The pharmacokinetic properties of sulphaperine-sodium, Mebacid 200, and sulphadimidine-sodium were experimentally established from fowl and mathematically objectivated. The highest half-life for elimination, coupled with low protein fixation, was recorded from sulphadimidine, by comparison of the above three sulphonamides. These data were used in dosage calculations for clinical testing.

100 Deals associated with Sulfaperin

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-	Sulfaperin	J01ED06	DB13320

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