100 Clinical Results associated with Nocaine/modafinil hybrid ligands(Acenta Discovery, Inc.)
100 Translational Medicine associated with Nocaine/modafinil hybrid ligands(Acenta Discovery, Inc.)
100 Patents (Medical) associated with Nocaine/modafinil hybrid ligands(Acenta Discovery, Inc.)
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Literatures (Medical) associated with Nocaine/modafinil hybrid ligands(Acenta Discovery, Inc.)01 Nov 2004·Journal of medicinal chemistryQ1 · MEDICINE
Piperidine-Based Nocaine/Modafinil Hybrid Ligands as Highly Potent Monoamine Transporter Inhibitors: Efficient Drug Discovery by Rational Lead Hybridization
Q1 · MEDICINE
Article
Author: He, Rong ; Zhou, Jia ; Kozikowski, Alan P. ; Johnson, Kenneth M. ; Ye, Yanping
Some piperidine-based nocaine/modafinil hybrid ligands have been designed, synthesized, and found to display an improved potency at all three monoamine transporters and particularly for DAT and/or NET. Some highly active and selective monoamine transporter inhibitors with low nanomolar to subnanomolar potency were identified. Ligands of this type may find important applications as positron emission tomography imaging tools and in the treatment of central nervous system disorders such as depression and sleep apnea.
100 Deals associated with Nocaine/modafinil hybrid ligands(Acenta Discovery, Inc.)