A review on the importance of genes of the major histocompatibility complex (MHC) locus in determining the risk and clin. course of sarcoidosis.The human leukocyte antigen (HLA) class II alleles associated with remitting or chronic disease in sarcoidosis are described.The mechanisms by which a peptide-specific T cell subset, exemplified by the trimol. complex MHC/peptide/T-cell receptor, influences disease remission are also discussed.

28 Jun 2002·ScienceQ1 · CROSS-FIELD

Getting Smaller and Smaller

Q1 · CROSS-FIELD

Letter

Author: Landry, Stuart

Robert F. Service's article on progress in developing miniature fuel cells for powering small electronic devices (“Shrinking fuel cells promise power in your pocket,” News Focus, 17 May, p. [1222][1]) is interesting and encouraging from the point of view of alternate energy strategies, but I wonder if the technology described is not already obsolete. Workable miniature fuel cells are coming on the market ([1][2]). The definition of a “fuel cell” should include not only cells using hydrogen and methanol, but also metal air cells. These are often called batteries, but they are not merely electricity-storing devices. Aluminum is especially interesting because the oxidation of aluminum produces enormous amounts of energy. To extract this energy in the usable form of electricity, aluminum is oxidized in an alkaline environment to aluminum hydroxide ([2][3]). Some of the more difficult problems of miniaturizing this technology have now been overcome ([3][4]). The Trimol Group is bringing out a unit 60 mm by 35 mm by 8 mm in size, which can power a wireless telephone for 25 hours of continuous talk ([1][2]). However depressing that prospect may be for the parents of teenagers, the problem of miniaturization of fuel cells has been solved. 1. [↵][5]See [www.trimolgroup.com/product_cellphone.htm][6]. 2. [↵][7]See [www.aluminum-power.com/technology.htm][8]. 3. [↵][9]See [fuelcell-magazine.com/articles/april101-2.htm][10]. [1]: /lookup/doi/10.1126/science.296.5571.1222 [2]: #ref-1 [3]: #ref-2 [4]: #ref-3 [5]: #xref-ref-1-1 "View reference 1 in text" [6]: http://www.trimolgroup.com/product_cellphone.htm [7]: #xref-ref-2-1 "View reference 2 in text" [8]: http://www.aluminum-power.com/technology.htm [9]: #xref-ref-3-1 "View reference 3 in text" [10]: http://fuelcell-magazine.com/articles/april01-2.htm

01 Dec 1996·Immunological ReviewsQ1 · MEDICINE

The HLA Likes and Dislikes of Allospecific and Non‐MHC‐Restricted Cytotoxic T Lymphocytes

Q1 · MEDICINE

Review

Author: Christine S. Falk ; Alexander Steinle ; Cahsten Reinhardt ; Elfrffide Nossner ; Petra Jantzer ; Dolores J. Schendel

A review with approx. 120 references of the authors' studies on cytotoxic effector T cells whose allospecificity is related to particular HLA-B and HLA-C mols.Phenotypic anal. of cell subsets has been combined with mol. characterization and expression of relevant MHC alleles to define the mol. basis of these responses.The role of peptides in determining the allospecificity of these cells was studied using TAP-deficient cell lines, transfected with relevant class I genes, as well as panels of genetically characterized target cells that express variant HLA mols.These approaches were combined with mol. TCR definition in order to assess the trimol. interaction of TCR with allogeneic class I mols. and their associated endogenous peptides.The authors also summarize their characterization of non-MHC-restricted cytotoxic effector cells that are inhibited by interactions with autologous and allogeneic class I mols.

100 Deals associated with Piroheptine Hydrochloride

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D01231	Piroheptine Hydrochloride	N04B	-

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Parkinson Disease	JP	Nihon Generic Co., Ltd.	01 Jan 1974

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