Last update 11 Sep 2025

PORT-77

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
2-((3S,6S,12aS)-9-chloro-6-isobutyl-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)-N,N-dimethylacetamide, PORT-77
Target
ABCG2
Action
inhibitors
Mechanism
ABCG2 inhibitors(Broad substrate specificity ATP-binding cassette transporter ABCG2 inhibitors)
Therapeutic Areas
Congenital DisordersDigestive System DisordersEndocrinology and Metabolic Disease+ [2]
Active Indication
Protoporphyria, Erythropoietic
Inactive Indication-
Originator Organization
Portal Therapeutics, Inc.
Active Organization
Portal Therapeutics, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
Login to view timeline

Related

2
Clinical Trials associated with PORT-77
NCT06971900
/ Enrolling by invitationPhase 2
A Phase 2a, Blinded, Randomized, Placebo-Controlled Study of PORT-77 Administered Orally to Adults With Erythropoietic Protoporphyria
NCT06346509
/ RecruitingPhase 1
A Phase 1, First-in-Human, Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose and Food Effect Study of PORT-77 Administered Orally to Healthy Adult Participants
100 Clinical Results associated with PORT-77
Login to view more data
100 Translational Medicine associated with PORT-77
Login to view more data
100 Patents (Medical) associated with PORT-77
Login to view more data
100 Deals associated with PORT-77
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Protoporphyria, ErythropoieticPhase 2
United States
Portal Therapeutics, Inc.
04 Apr 2025
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free