99mTc N-Isonitrile Glucosamine

Primary objective: To evaluate the safety and tolerability of 99mTc-CNDG7 injection at different doses in Chinese healthy subjects and patients with non-small cell lung cancer (NSCLC). Secondary objectives: (1) To evaluate the biodistribution and radiation dosimetry characteristics of 99mTc-CNDG7 injection in Chinese healthy subjects and patients with NSCLC. (2) To evaluate the pharmacokinetic characteristics and metabolic stability of 99mTc-CNDG7 injection in Chinese healthy subjects and patients with NSCLC. (3) To preliminarily evaluate the effects of different radioactive administration doses on the image quality of single photon emission computed tomography (SPECT)/CT scanning and the target-to-body ratio (TBR) of tumor lesions of 99mTc-CNDG7 injection, and to provide a reference for imaging conditions in later clinical trials. (4) To evaluate the radiation safety of the use of 99mTc-CNDG7 injection on the environment and medical staff.