Last update 18 Apr 2026

TJ-109

Overview

Basic Info

Drug Type
Dual payload Antibody drug conjugate (Dual payload ADC)
Synonyms
TJ 109, TJ109
Target
EGFR x HER3 x Top I x Tubulin
Action
antagonists, inhibitors
Mechanism
EGFR antagonists(Epidermal growth factor receptor erbB1 antagonists), HER3 antagonists(Receptor tyrosine-protein kinase erbB-3 antagonists), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication-
Inactive Indication
Non-Small Cell Lung Cancer
Originator Organization
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
Active Organization-
Inactive Organization
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
License Organization-
Drug Highest PhaseDiscontinuedPreclinical
First Approval Date-
Regulation-

Structure/Sequence

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Related

100 Clinical Results associated with TJ-109
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100 Translational Medicine associated with TJ-109
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100 Patents (Medical) associated with TJ-109
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1
Literatures (Medical) associated with TJ-109
01 Nov 2010Complementary therapies in clinical practiceQ4 · MEDICINE
Sho-saiko-to-ka-kikyo-sekko as an alternative treatment for chronic tonsillitis to avoid surgery
Q4 · MEDICINE
100 Deals associated with TJ-109
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Non-Small Cell Lung CancerPreclinical
China
Phrontline Biopharma (Suzhou) Co., Ltd.Phrontline Biopharma (Suzhou) Co., Ltd.
01 Jun 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Translational Medicine

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Deal

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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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