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Last update 20 Mar 2025

Phenylpropanol

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Phenylpropanol (JAN)

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Biliary Tract DiseasesGastrointestinal Diseases

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC9H12O

InChIKeyDYUQAZSOFZSPHD-UHFFFAOYSA-N

CAS Registry93-54-9

100 Clinical Results associated with Phenylpropanol

100 Translational Medicine associated with Phenylpropanol

100 Patents (Medical) associated with Phenylpropanol

2,836

Literatures (Medical) associated with Phenylpropanol

01 Apr 2025·Synlett

Borane-Catalyzed Divergent para and ortho C-Alkylation of Arylamines Using Benzylic Alcohols

Author: Hu, Hao-Lan ; Jiang, Yi-Jun ; Shi, Jianghuan ; Chen, Peng ; Niu, Yu-Dan ; Li, Meng-Yuan

AbstractA catalyst-controlled divergent alkylation of diarylamines with benzylic alcohols has been developed. A para C-alkylation of diarylamines could be achieved by using B(C6F5)3 as the catalyst, whereas ortho C-alkylation of diarylamines could be achieved by using HBF4·Et2O as the catalyst. The salient features of this transformation include readily available materials, a broad substrate scope, easily available catalysts, and simple and mild reaction conditions.

03 Mar 2025·Chemistry – An Asian Journal

Ligand Assisted Co(II)‐Catalyzed Multicomponent Synthesis of Substituted Pyrroles and Pyridines

Article

Author: Mandal, Sutanuva ; Paul, Nanda D. ; Singha Mohapatra, Arijit ; Saha, Subhangi ; Chakraborty, Subhajit

AbstractHerein, we describe a sustainable Co(II)‐catalyzed synthesis of pyrroles and pyridines. Using a Co(II)‐catalyst [CoII2(La)2Cl2] (1 a) bearing redox‐active 2‐(phenyldiazenyl)‐1,10‐phenanthroline) (La) scaffold, various substituted pyrroles and pyridines were synthesized in good yields, taking alcohol as one of the primary feedstock. Pyrroles were synthesized by the equimolar reaction of 2‐amino and secondary alcohols. A series of 2,4,6‐substituted symmetrical pyridines were prepared via a three‐component reaction of NH4OAc with 1 : 2.2 molar primary and secondary alcohols, respectively. Unsymmetrically substituted 2,4,6‐trisubstituted, 2,4,5,6‐tetrasubstituted, and 2,3,4,5,6‐pentasubstituted pyridines were achieved via a multi‐component coupling reaction of alcohols and NH4OAc. Catalyst 1 a showed encouraging results during the gram‐scale synthesis of these N‐heterocycles. Mechanistic investigation revealed synergistic involvement of cobalt metal and the ligand during the catalytic reactions.

01 Mar 2025·Synthesis

Scandium(III)-Catalyzed N-Alkylation of Carbazoles with Alcohols

Author: Niu, Yu-Dan ; Hu, Hao-Lan ; Chen, Peng ; Shi, Jianghuan ; Jiang, Yi-Jun ; Lv, Pei

AbstractA general and efficient protocol has been developed for the N-alkylation of carbazoles with benzylic alcohols via scandium-catalyzed reaction. This transformation proceeds smoothly under an air atmosphere and features simple reaction conditions and wide substrate scope, which deliver a variety of N-alkylated carbazoles with up to 99% yields and broad functional group compatibilities.

100 Deals associated with Phenylpropanol

External Link

KEGG	Wiki	ATC	Drug Bank
D01470	-	A	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Biliary Tract Diseases	-	-	-
Gastrointestinal Diseases	-	-	-

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