RATIONALEThe subjective, psychomotor, and physiological effects of prescription compounds containing the opioid hydrocodone have not been studied in a population of non-drug-abusing people who might be prescribed these compounds for cough or pain relief.OBJECTIVESTo characterize the effects of a hydrocodone combination product, Hycodan, which contains hydrocodone and a peripherally-acting anticholinergic, homatropine, in non-drug-abusing volunteers.METHODSEighteen volunteers participated in a crossover, double-blind study in which they received placebo; 5 mg hydrocodone/1.5 mg homatropine, 10 mg hydrocodone/3 mg homatropine, 20 mg hydrocodone/6 mg homatropine (all PO); 40 mg morphine (PO); and 2 mg lorazepam (PO). Measures were assessed before and for 300 min after drug administration. End-of-session and 24-h measures were taken to assess residual drug effects and overall subjects' assessment of the drug effects. RESULTS. Subjective effects of the hydrocodone/homatropine combination were dose-related, although the majority of statistically significant effects were limited to the highest dose combination tested. A combination of 20 mg hydrocodone/6 mg homatropine and morphine had a similar profile of subjective effects, which included both pleasant and unpleasant effects. Peak liking ratings were increased by 20 mg hydrocodone/6 mg homatropine and morphine, and trough ratings of liking (dislike) were lower in the 20 mg hydrocodone/6 mg homatropine condition, relative to the placebo condition. Post-session ratings of overall liking were not significant, either at the end of the session or 24 h later. Cognitive and psychomotor impairment were more marked with lorazepam than with hydrocodone/homatropine and morphine. Miosis and exophoria were increased in a dose-related manner by hydrocodone/homatropine.CONCLUSIONSHycodan at the highest dose tested had effects similar to that of a prototypic mu agonist, morphine. Both drugs produced pleasant (including drug liking) as well as unpleasant subjective effects. Post-session ratings of overall liking and "want to take drug again" were not significant.

01 Apr 1946·American review of tuberculosis

Hycodan; dihydrocodeinone.

Article

Author: LOWY, P ; STEIN, P

Hycodan (dihydrocodeinone bitartrate) can be characterized pharmacologically as a more active analgesic and cough sedative than codeine, but a less active one than morphine.It shows a favorable ratio between analgesic and toxic effects and has a relatively low addiction liability.In therapeutic doses, it does not produce vomiting and its constipative effect appears to be insignificant.For pulmonary diseases hycodan proved to be highly effective in sedation of cough and in the alleviation of pain.

100 Deals associated with Homatropine Methylbromide/Hydrocodone Bitartrate

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KEGG	Wiki	ATC	Drug Bank
-	Homatropine Methylbromide/Hydrocodone Bitartrate	R05D	DBSALT001233

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Indication	Country/Location	Organization	Date
Cough	US	Genus Lifesciences, Inc.	23 Mar 1943

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