Delving into the Latest Updates on Wogonin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

AR x IL-6 x TNF-α

Action

antagonists, inhibitors

Mechanism

AR antagonists(Androgen Receptor antagonists), IL-6 inhibitors(Interleukin-6 inhibitors), TNF-α inhibitors(Tumor necrosis factor α inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Neoplasms

Inactive Indication-

Originator Organization

Hefei Heyuan Pharmaceutical Technology Co. Ltd.

Active Organization

China Pharmaceutical University

Hefei Heyuan Pharmaceutical Technology Co. Ltd.

Inactive Organization-

License Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC16H12O5

InChIKeyXLTFNNCXVBYBSX-UHFFFAOYSA-N

CAS Registry632-85-9

Skin hyperpigmentation is a type of difficult-to-treat disease that frequently results from the improper metabolism of facial pigment. The herb Forsythiae Fructus (FF) possesses whitening and freckle-removal properties. Its probable active components and anti-hyperpigmentation mechanism, however, are still unknown. In the current investigation, the active components were initially identified and screened by UHPLC-Q-Orbitrap HRMS/MS employing B16 cell-specific extraction and plasma pharmaceutical chemistry, respectively. Subsequently, the component-target-disease network and protein-protein interaction (PPI) network of FF were built by using a network pharmacology approach. The probable targets and pathways were found using gene ontology (GO) and KEGG enrichment analysis. The essential elements and core genes causing illnesses were identified through molecular docking. Lastly, based on network analysis, cell experiments were carried out to further explore the efficacy of the main active ingredients in the treatment of abnormal melanosis. As a result, 37 ingredients were identified in FF extract, 22 compounds in the decoction had a specific affinity with B16 mouse melanoma cells, and a total of 10 prototype compounds and 11 metabolites were detected in rat plasma. Through in vitro and in vivo screening methods, 16 potential active ingredients were obtained, and 229 biological targets and 1515 disease-related targets were predicted by network pharmacology. In addition, in vitro cell experiments revealed that kaempferol, luteolin, and wogonin all exhibited inhibition of melanin production and tyrosinase activity. The proposed combination method of rapid screening of active ingredients in vivo and integrated network pharmacology in vitro could explore the therapeutic mechanism of FF against hyper-pigmentation, and provide a theoretical evidence for the development and utilization of FF.

01 Sep 2025·FOOD CHEMISTRY

Antioxidant analysis and quality standardization of Scutellaria baicalensis tablets using multidimensional analytical methodologies

Article

Author: Sun, Guoxiang ; Zhang, Jianglei ; Lan, Lili ; Xiu, Xiaojie ; Zeng, Jin

Scutellaria baicalensis Tablets (SBTs), sourced from the root of Scutellaria baicalensis Georgi, demonstrated notable potential as natural antioxidants for functional-food development. To comprehensively evaluate SBT quality and antioxidant capacity, we developed an integrated analytical workflow combining electronic-transition-theory-driven multi-wavelength concatenation, a binary evaluation system (BES), dual-channel high-performance liquid chromatography-online antioxidant activity coupling (DC-HPLC-OAA), and electrochemical profile integration. First, guided by electronic-transition theory, the multi-wavelength concatenation captured subtle inter-flavonoid variations across several wavelengths, thereby surmounting the constraints of single-wavelength detection. Second, the binary evaluation system, combining S_m and quantitative P_m parameters, provided a multidimensional appraisal of product quality, correlating robustly with key-component levels (e.g., baicalin). Chemometric analysis further confirmed the precision and reliability of S_m and P_m, yielding a triadic framework: "high-dimensional data dimensionality reduction-key component mapping-quality threshold determination." Third, DC-HPLC-OAA systematically screened the antioxidant activities of major flavonoids (baicalin, baicalein, wogonin), whose cumulative capacities were then quantified by electrochemical profile integration. Collectively, this integrated approach established a robust foundation for precise SBT quality control and underscored their promise as natural antioxidant ingredients in functional foods.

01 Aug 2025·COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Jingzhi Niuhuangjiedu Tablet Ameliorates Oral Mucositis via the AKT/NFκB/NLRP3 Signaling Pathway: A Network Pharmacology and Experimental Validation

Article

Author: Zhao, Chen ; Wang, Zijian ; Wang, Hongping ; Wang, Zhibin ; Lv, Yingnan ; Li, Pin ; Fan, Chunlan ; Ma, Quantao ; Peng, Ping ; Yin, Qiong ; Lin, Zhaozhou

Background::

Oral Mucositis (OM) is a common and highly symptomatic complication of cancer therapy that affects patient function and quality of life. Jingzhi Niuhuangjiedu Tablet (JNT) is derived from the famous Chinese herbal formulas Huanglian Jiedu and Fangfeng Tongsheng decoctions, which have been widely used to treat heat toxin syndrome diseases, such as acute pharyngitis, periodontitis, oral ulcers, and oral mucositis (OM), but the underlying mechanism remains unclear.

Objectives::

This study validated the efficacy and explored the potential mechanisms of JNT in the treatment of OM by integrating network pharmacological analyses and experimental verification.

Methods::

Network pharmacology and molecular docking techniques were used to predict the active components, key targets, and potential mechanisms of action of JNT against OM. The rat OM model was established by administering 5-Fluorouracil (5-FU) and acetic acid to the rat oral mucosa. Lipopolysaccharide (LPS)-treated human gingival fibroblasts (HGFs) were used as an inflammatory cell model. The GFP-NFκB HEK293T cell line was transfected to evaluate the anti-NFκB activity of JNT.

Results::

A total of 236 Chinese herbal components and 201 corresponding targets were predicted for OM treatment using JNT. Bicuculine, luteolin, wogonin, and naringenin were identified as the important active compounds, while AKT1, ALB, IL6, MAPK3, and VEGFA were considered to be the major targets. Molecular docking revealed that these active compounds exhibited strong binding interactions with their targets. In vivo and in vitro experiments demonstrated that the anti-OM effect of JNT might be closely related to AKT1, NFκB, caspase-1, and NLRP3, as well as biological processes, such as inflammatory response and oxidative stress.

Conclusion::

Network pharmacological and experimental evidence indicates that JNT has a potential therapeutic effect on OM by regulating the Akt/NFκB/NLRP3 pathway.

100 Deals associated with Wogonin

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